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1.

Relation between chronic rhinosinusitis and gastroesophageal reflux in adults: systematic review/ Relação entre rinossinusite crônica e refluxo gastroesofágico em adultos: revisão sistemática

Sella, Guilherme Constante Preis; Tamashiro, Edwin; Anselmo-Lima, Wilma Terezinha; Valera, Fabiana Cardoso Pereira
Evidence in LILACS | Language(s): English
Abstract Introduction: The relationship between gastroesophageal reflux disease (GERD) and chronic rhinosinusitis (CRS) is still a controversial issue in literature. Objective: A systematic review of the association between these two diseases in adult patients. Methods: Systematic review in PubMed and Cochrane Database with articles published between 1951 and 2015. We included all articles that specifically studied the relationship between CRS and GERD. Results: Of the 436 articles found, only 12 met the inclusion criteria. Eight cross-sectional articles suggest a relation between CRS and GERD, especially on CRS that is refractory to clinical or surgical treatment. However, the groups are small and methodologies are different. Four other longitudinal studies have as (more)
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2.

Hearing thresholds at high frequency in patients with cystic fibrosis: a systematic review/ Limiares auditivos em altas frequências em pacientes com fibrose cística: revisão sistemática

Caumo, Debora T.M.; Geyer, Lúcia B.; Teixeira, Adriane R.; Barreto, Sérgio S.M.
Evidence in LILACS | Language(s): English
Abstract Introduction: High-frequency audiometry may contribute to the early detection of hearing loss caused by ototoxic medications. Many ototoxic drugs are widely used in the treatment of patients with cystic fibrosis. Early detection of hearing loss should allow known harmful drugs to be identified before the damage affects speech frequencies. The damage caused by ototoxicity is irreversible, resulting in important social and psychological consequences. In children, hearing loss, even when restricted to high frequencies, can affect the development of language. Objective: To investigate the efficacy and effectiveness of hearing monitoring through high-frequency audiometry in pediatric patients with cystic fibrosis. Methods: Electronic databases PubMed, MedLine, We (more)
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3.

Aging and wave-component latency delays in oVEMP and cVEMP: a systematic review with meta-analysis/ Envelhecimento e os atrasos nas latências das componentes de onda no oVEMP e no cVEMP: uma revisão sistemática com metanálise

Macambira, Ysa Karen dos Santos; Carnaúba, Aline Tenório Lins; Fernandes, Luciana Castelo Branco Camurça; Bueno, Nassib Bezerra; Menezes, Pedro de Lemos
Evidence in LILACS | Language(s): English
Abstract Introduction: The natural aging process may result in morphological changes in the vestibular system and in the afferent neural pathway, including loss of hair cells, decreased numbers of vestibular nerve cells, and loss of neurons in the vestibular nucleus. Thus, with advancing age, there should be a decrease in amplitudes and an increase in latencies of the vestibular evoked myogenic potentials, especially the prolongation of p13 latency. Moreover, many investigations have found no significant differences in latencies with advancing age. Objective: To determine if there are significant differences in the latencies of cervical and ocular evoked myogenic potentials between elderly and adult patients. Methods: This is a systematic review with meta-analysis of (more)
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4.

Association between desloratadine and prednisolone in the treatment of children with acute symptoms of allergic rhinitis: a double-blind, randomized and controlled clinical trial/ Associação entre desloratadina e prednisolona no tratamento de crianças com sintomas agudos de rinite alérgica: ensaio clínico duplo-cego, randomizado e controlado

Wandalsen, Gustavo F.; Miranda, Carolina; Ensina, Luis Felipe; Sano, Flavio; Amazonas, Roberto Bleul; Silva, Joyce Macedo da; Solé, Dirceu
Evidence in LILACS | Language(s): English
Abstract Introduction: A combination of antihistamines and oral corticosteroids is often used to treat acute symptoms of allergic rhinitis. Objective: To evaluate safety and efficacy of desloratadine plus prednisolone in the treatment of acute symptoms of children (2-12 years) with allergic rhinitis, and to compare it to dexchlorpheniramine plus betamethasone. Methods: Children with moderate/severe persistent allergic rhinitis and symptomatic (nasal symptoms score [0-12] ≥ 6) were allocated in a double-blind, randomized fashion to receive dexchlorpheniramine plus betamethasone (n = 105; three daily doses) or desloratadine plus prednisolone (n = 105; single dose followed by two of placebo) for 7 days. At the beginning and end of the evaluation, the following wer (more)
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5.

Significant association between osteoporosis and hearing loss: a systematic review and meta-analysis/ Associação significativa entre osteoporose e perda auditiva: uma revisão sistemática e metanálise

Upala, Sikarin; Rattanawong, Pattara; Vutthikraivit, Wasawat; Sanguankeo, Anawin
Evidence in LILACS | Language(s): English
Abstract Introduction: There is inconclusive evidence whether osteoporosis increases risk of hearing loss in current literature. Objective: We conducted this meta-analysis to determine whether there is an association between hearing loss and osteoporosis. Methods: This systematic review and meta-analysis was conducted from studies of MEDLINE, EMBASE, and LILACS. Osteoporosis was defined as having a bone mineral density with a T-score of less than −2.5 standard deviation. The outcome was hearing loss as assessed by audiometry or self-reported assessment. Random-effects model and pooled hazard ratio, risk ratio, or odds ratio of hearing loss with 95% confidence intervals were compared between normal bone mineral density and low bone mineral density or osteoporosi (more)
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6.

Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review/ Polimorfismos na rinossinusite crônica com pólipos nasais - uma revisão sistemática

Dinarte, Vanessa Ramos Pires; Santos, Anemari Ramos Dinarte dos; Araújo, Luiza Ferreira de; Reis, Mariah Guieiro Alves dos; Tamashiro, Edwin; Valera, Fabiana Cardoso Pereira; Silva Júnior, Wilson Araújo da; Anselmo-Lima, Wilma Terezinha
Evidence in LILACS | Language(s): English
Abstract Introduction: Chronic rhinosinusitis with nasal polyps is a multifactorial disease with a complex pathophysiology involving multiple genetic and environmental factors. Objective: The purpose of this work review is to focus on the importance of genetic studies in chronic rhinosinusitis with nasal polyps besides the several barriers that exists for its understanding. Methods: A systematic review on studies of association between single nucleotide polymorphisms and chronic rhinosinusitis with nasal polyps based on a PubMed/Medline and Periódicos CAPES search of all articles published between January 2005 and January 2015 was made. The search was guided on studies containing the terms polymorphisms, rhinosinusitis, and polyps. Results: Two studies found an ass (more)
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7.

Effectiveness of Otolith Repositioning Maneuvers and Vestibular Rehabilitation exercises in elderly people with Benign Paroxysmal Positional Vertigo: a systematic review/ Eficácia das manobras de reposicionamento de otólitos e exercícios de reabilitação vestibular em idosos com vertigem posicional paroxística benigna: uma revisão sistemática

Ribeiro, Karyna Figueiredo; Oliveira, Bruna Steffeni; Freitas, Raysa V.; Ferreira, Lidiane M.; Deshpande, Nandini; Guerra, Ricardo O.
Evidence in LILACS | Language(s): English
Abstract Introduction Benign Paroxysmal Positional Vertigo is highly prevalent in elderly people. This condition is related to vertigo, hearing loss, tinnitus, poor balance, gait disturbance, and an increase in risk of falls, leading to postural changes and quality of life decreasing. Objective To evaluate the outcomes obtained by clinical trials on the effectiveness of Otolith Repositioning Maneuver and Vestibular Rehabilitation exercises in the treatment of Benign Paroxysmal Positional Vertigo in elderly. Methods The literature research was performed using PubMed, Scopus, Web of Science and PEDro databases, and included randomized controlled clinical trials in English, Spanish and Portuguese, published during January 2000 to August 2016. The methodological quality (more)
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8.

Influence of dietary and physical activity restriction on pediatric adenotonsillectomy postoperative care in Brazil: a randomized clinical trial/ Influência das restrições dietéticas e de atividade física no pós-operatório da adenotonsilectomia em pacientes pediátricos no Brasil: ensaio clínico randomizado

Manica, Denise; Sekine, Leo; Abreu, Larissa S.; Manzini, Michelle; Rabaioli, Luísi; Valério, Marcel M.; Oliveira, Manoela P.; Bergamaschi, João A.; Fernandes, Luciano A.; Kuhl, Gabriel; Schweiger, Cláudia
Evidence in LILACS | Language(s): English
Abstract Introduction Although culturally food and physical activity restriction are part of the routine postoperative care of many Brazilian surgeons, current evidences from other countries support no such recommendations. Objective To determine whether dietary and physical restriction effectively lead to a decrease on postoperative complications of adenotonsillectomy in children when compared to no restriction. Methods We have designed a randomized clinical trial comparing two intervention: no specific counseling on diet or activity (Group A), and restriction recommendations on diet and physical activities (Group B). Caregivers completed a questionnaire on observed pain, diet and activity patterns, and medications administered. Parameters were compared at the 3rd a (more)
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9.

Cost-consequence analysis of Pharmaceutical Care program for systemic arterial hypertension in the public health system in Brazil

Cazarim, Maurílio de Souza; Nunes, Altacílio Aparecido; Pereira, Leonardo Régis Leira
Evidence in LILACS | Language(s): English
ABSTRACT In Brazil, 80% of hypertensive patients have no blood pressure controlled, this fact has caused severe financial consequences for the public health system (PHS) and the Pharmaceutical Care (PC) has emerged as an effective alternative. The aim of this study was to analyze the costs and outcomes of systemic arterial hypertension (SAH) for conventional assistance compared to assistance with PC in the PHS. This is a pharmacoeconomic study with cost-consequence analysis nested to clinical trial. Hypertensives patients were followed-up from 2006 to 2012. During 2009 they were assisted by the PC program in Ribeirão Preto-SP, Brazil. Clinical indicators, systolic and diastolic blood pressure (SBP and DBP), triglycerides, total cholesterol (TC) and its fractions and he (more)
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10.

Pharmacists in dispensing drugs (PharmDisp): protocol for a clinical trial to test the effectiveness of distance education in training pharmacists for dispensing drugs

Reis, Tiago Marques dos; Guidoni, Camilo Molino; Baldoni, André Oliveira; Giroto, Edmarlon; Obreli Neto, Paulo Roque; Ayres, Lorena Rocha; Pereira, Leonardo Régis Leira
Evidence in LILACS | Language(s): English
ABSTRACT Dispensing drug is a moment in which the pharmacist is able to analyze pharmacotherapy and contribute to its rational use. However, research has shown that some pharmacists lack adequate knowledge to perform this service. This study aims to describe a research protocol for a clinical trial to test the effectiveness of a distance learning program to train pharmacists in dispensing drugs. This is a protocol for an open diagnostic, non-randomized, single group clinical trial. A 12-week duration distance learning course was structured on the Moodle platform for training community pharmacists who are registered in the Regional Board of Pharmacy and work as employees or owners in Brazilian community pharmacies. The course curricula involves concepts and practice of d (more)
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11.

Efficiency of polymerization of bulk-fill composite resins: a systematic review

REIS, André Figueiredo; VESTPHAL, Mariana; AMARAL, Roberto Cesar do; RODRIGUES, José Augusto; ROULET, Jean-François; ROSCOE, Marina Guimarães
Evidence in LILACS | Language(s): English
Abstract This systematic review assessed the literature to evaluate the efficiency of polymerization of bulk-fill composite resins at 4 mm restoration depth. PubMed, Cochrane, Scopus and Web of Science databases were searched with no restrictions on year, publication status, or article's language. Selection criteria included studies that evaluated bulk-fill composite resin when inserted in a minimum thickness of 4 mm, followed by curing according to the manufacturers' instructions; presented sound statistical data; and comparison with a control group and/or a reference measurement of quality of polymerization. The evidence level was evaluated by qualitative scoring system and classified as high-, moderate- and low- evidence level. A total of 534 articles were retrieved (more)
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12.

Randomized clinical trials of dental bleaching - Compliance with the CONSORT Statement: a systematic review

LOGUERCIO, Alessandro Dourado; MARAN, Bianca Medeiros; HANZEN, Taíse Alessandra; PAULA, Alexandra Mara de; PERDIGÃO, Jorge; REIS, Alessandra
Evidence in LILACS | Language(s): English
Abstract We reviewed the literature to evaluate: a) The compliance of randomized clinical trials (RCTs) on bleaching with the CONSORT; and b) the risk of bias of these studies using the Cochrane Collaboration risk of bias tool (CCRT). We searched the Cochrane Library, PubMed and other electronic databases, to find RCTs focused on bleaching (or whitening). The articles were evaluated in compliance with CONSORT in a scale: 0 = no description, 1 = poor description and 2 = adequate description. Descriptive analyses of the number of studies by journal, follow-up period, country and quality assessments were performed with CCRT for assessing risk of bias in RCTs. 185 RCTs were included for assessment. More than 30% of the studies received score 0 or 1. Protocol, flow chart, al (more)
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13.

Duration of effectiveness of Botulinum toxin type A in excessive gingival display: a systematic review and meta-analysis

Chagas, Taísa Figueiredo; Almeida, Natalia Valli de; Lisboa, Cinthia Oliveira; Ferreira, Daniele Masterson Tavares Pereira; Mattos, Claudia Trindade; Mucha, José Nelson
Evidence in LILACS | Language(s): English
Abstract Botulinum toxin type A is effective in reducing excessive gingival display caused by hyperfunctional upper lip elevator muscles; however, this effect is transient. This study aimed to determine the duration of the effectiveness of botulinum toxin type A on a gummy smile. A systematic search was conducted using Medline (PubMed), Scopus, and Web of Science electronic databases, from 1970 to March 2017 with no language restriction; the search included studies evaluating adult patients with excessive gingival display who were treated with botulinum toxin and were followed-up for at least 3 months. OpenGrey and Clinical Trial Registry were also consulted. Quality assessment was applied to determine the level of evidence and bias, and a meta-analysis was performed. O (more)
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14.

Oral health related quality of life among pregnant women: a randomized controlled trial

Musskopf, Marta Liliana; Milanesi, Fernanda Carpes; Rocha, José Mariano da; Fiorini, Tiago; Moreira, Carlos Heitor Cunha; Susin, Cristiano; Rösing, Cassiano Kuchenbecker; Weidlich, Patricia; Oppermann, Rui Vicente
Evidence in LILACS | Language(s): English
Abstract: The aim of the present study was to compare negative impacts of oral conditions in Oral Heath Related Quality of Life (OHRQoL) assessed by the Oral Health Impact Profile-14 (OHIP-14) scores in pregnant women receiving or not comprehensive periodontal treatment. This randomized controlled clinical trial included pregnant women aged between 18 and 35 years old. Participants were randomized in a test group with 96 and a control group with 114 women. Patients in the test group received comprehensive periodontal treatment, supra and subgingival scaling and root-planning and periodontal maintenance appointments. The OHIP-14 was applied before and after treatment. The primary outcome was changes in OHIP-14 scores after follow-up period. The impact of having received (more)
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15.

A multicenter study of oral health behavior among adult subjects from three South American cities

Gómez, Mariel Viviana; Toledo, Andrés; Carvajal, Paola; Gomes, Sabrina Carvalho; Costa, Ricardo Santos Araújo; Solanes, Fernando; Oppermann, Rui Vicente; Rösing, Cassiano Kuchenbecker; Gamonal, Jorge; Romanelli, Hugo
Evidence in LILACS | Language(s): English
Abstract The aims of this study were to describe the self-reported oral hygiene habits, dental visit frequency, and gingival bleeding perception in adult populations from three South American cities, and also to assess the association of these variables with sociodemographic data and with the clinical presence of plaque and gingival inflammation. Five-hundred and fifty adult subjects from each city (Porto Alegre, Brazil; Tucumán, Argentina; Santiago, Chile) received full mouth examinations to determine visible plaque and gingival index. A structured questionnaire on demographics, habits, attitudes and knowledge of oral health was also administered. The data were analyzed according to dental visit frequency, toothbrushing frequency, interproximal tooth cleaning frequenc (more)
Results  1-15 de 49.353