La Literatura Científica sobre las Enfermedades Infecciosas Relacionada con TropIKA.net

La Literatura Científica sobre las Enfermedades Infecciosas Relacionada con TropIKA.net

 

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Resultados  1-15 de 1.750
1.

Subtractive Phage Display Selection from Canine Visceral Leishmaniasis Identifies Novel Epitopes That Mimic Leishmania infantum Antigens with Potential Serodiagnosis Applications.

Autor(es): Costa LE; Lima MI; Chávez-Fumagalli MA; Menezes-Souza D; Martins VT; Duarte MC; Lage PS; Lopes EG; Lage DP; Ribeiro TG; Andrade PH; de Magalhães-Soares DF; Soto M; Tavares CA; Goulart LR; Coelho EA; Wilkins PP
Fuente: Clin Vaccine Immunol; 21(1): 96-106, 2014 Jan.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: Visceral leishmaniasis (VL) is a zoonotic disease that is endemic to Brazil, where dogs are the main domestic parasite reservoirs, and the percentages of infected dogs living in regions where canine VL (CVL) is endemic have ranged from 10% to 62%. Despite technological advances, some problems have been reported with CVL serodiagnosis. The present study describes a sequential subtractive selection through phage display technology from polyclonal antibodies of negative and positive sera that (mas)
2.

Cross-protective effect of a combined L5 plus L3 Leishmania major ribosomal protein based vaccine combined with a Th1 adjuvant in murine cutaneous and visceral leishmaniasis.

Autor(es): Ramirez L; Corvo L; Duarte MC; Chávez-Fumagalli MA; Valadares DG; Santos DM; de Oliveira CI; Escutia MR; Alonso C; Bonay P; Tavares CA; Coelho EA; Soto M
Fuente: Parasit Vectors; 7(1): 3, 2014.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: BACKGROUND: Two Leishmania major ribosomal proteins L3 (LmL3) and L5 (LmL5) have been described as protective molecules against cutaneous leishmaniasis due to infection with L. major and Leishmania braziliensis in BALB/c mice when immunized with a Th1 adjuvant (non-methylated CpG-oligodeoxynucleotides; CpG-ODN). In the present study we analyzed the cross-protective efficacy of an LmL3-LmL5-CpG ODN combined vaccine against infection with Leishmania amazonensis and Leishmania chagasi (syn. Le (mas)
3.

Leishmaniasis: clinical syndromes and treatment.

Autor(es): McGwire BS; Satoskar AR
Fuente: QJM; 107(1): 7-14, 2014 Jan.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: Leishmaniasis is a global term for cutaneous and visceral anthroponotic and zoonotic diseases caused by the vector-borne parasites of the genus Leishmania. These diseases afflict at least 2 million people each year with more than 350 million at risk in 98 countries worldwide. These are diseases mostly of the impoverished making prevention, diagnosis and treatment difficult. Therapy of leishmaniasis ranges from local treatment of cutaneous lesions to systemic, often toxic, therapy for dissem (mas)
4.

Natural product based leads to fight against leishmaniasis.

Autor(es): Singh N; Mishra BB; Bajpai S; Singh RK; Tiwari VK
Fuente: Bioorg Med Chem; 22(1): 18-45, 2014 Jan 1.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: The growing incidence of parasitic resistance against generic pentavalent antimonials, specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania control. Notwithstanding the two treatment alternatives, that is amphotericin B and miltefosine are being effectively used but their high cost and therapeutic complications limit their use in endemic areas. In the absence of a vaccine candidate, identification, and characterization of novel drugs and targets is a ma (mas)
5.

CD8 T cell exhaustion in human visceral leishmaniasis.

Autor(es): Gautam S; Kumar R; Singh N; Singh AK; Rai M; Sacks D; Sundar S; Nylén S
Fuente: J Infect Dis; 209(2): 290-9, 2014 Jan.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: Little is known about CD8 T cells in human visceral leishmaniasis (VL) and it is unclear if these cells have a protective, pathological and/or suppressive function. In experimental VL CD8 T cells have been shown to contribute to parasite control and play an important role in vaccine-generated immunity. To better understand the role of CD8 T cells in human VL, we examined molecules associated with anergy and cytotoxic T lymphocytes (CTL) in peripheral blood mononuclear cells (PBMC) and splen (mas)
6.

Field evaluation of alphacypermethrin in indoor residual spraying for leishmaniasis control in an endemic area, northern Morocco.

Autor(es): Faraj C; Adlaoui el B; Ouahabi S; Elkohli M; Elrhazi M; Laqraa L; Ameur B
Fuente: Parasit Vectors; 6(1): 354, 2013.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: BACKGROUND: In Morocco, the main strategies of leishmaniasis vector control are based on environmental modifications. Use of local residual indoor spraying with synthetic pyrethroids is often envisaged. The need to evaluate this control method is essential. The current study was conducted to determine the efficacy of an alphacypermethrin IRS program against leishmaniasis vectors in an endemic area in the north of Morocco. METHODS: The survey was conducted in four neighbouring localities in (mas)
7.

Cost-effectiveness of prevention strategies for American tegumentary leishmaniasis in Argentina.

Autor(es): Orellano PW; Vazquez N; Salomon OD
Fuente: Cad Saude Publica; 29(12): 2459-72, 2013 Dec.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: The aim of this study was to estimate the cost-effectiveness of reducing tegumentary leishmaniasis transmission using insecticide-impregnated clothing and curtains, and implementing training programs for early diagnosis. A societal perspective was adopted, with outcomes assessed in terms of costs per disability adjusted life years (DALY). Simulation was structured as a Markov model and costs were expressed in American dollars (US$). The incremental cost-effectiveness ratio of each strategy (mas)
8.

Cost-effectiveness of prevention strategies for American tegumentary leishmaniasis in Argentina/ Custo-efetividade de estratégias de prevenção contra a leishmaniose tegumentar americana na Argentina/ Coste-efectividad de estrategias de prevención contra la leishmaniasis tegumentaria americana en Argentina

Autor(es): Orellano, Pablo Wenceslao; Vazquez, Nestor; Salomon, Oscar Daniel
Fuente: Cad Saude Publica; 29(12): 2459-2472, Dec. 2013. ilus, tab.
LILACS - Literatura Latinoamericana y del Caribe en Ciencias de la Salud
Idioma: Inglés
Resumen: O objetivo deste estudo foi estimar o custo-efetividade para reduzir a transmissão da leishmaniose tegumentar americana, utilizando roupas e cortinas impregnadas com inseticidas e implementando programas de treinamento para o diagnóstico precoce. Adotou-se uma perspectiva social, usando os anos de vida ajustados por incapacidade (AVAI). Estruturou-se uma simulação com o modelo de Markov. Os custos foram expressos em US$. A taxa de custo-efetividade incremental foi calculada para c (mas)
9.

Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function.

Autor(es): Esch KJ; Juelsgaard R; Martinez PA; Jones DE; Petersen CA
Fuente: J Immunol; 191(11): 5542-50, 2013 Dec 1.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Resumen: Control of Leishmania infantum infection is dependent upon Th1 CD4(+) T cells to promote macrophage intracellular clearance of parasites. Deficient CD4(+) T cell effector responses during clinical visceral leishmaniasis (VL) are associated with elevated production of IL-10. In the primary domestic reservoir of VL, dogs, we define occurrence of both CD4(+) and CD8(+) T cell exhaustion as a significant stepwise loss of Ag-specific proliferation and IFN-γ production, corresponding to increa (mas)
10.

A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis.

Autor(es): Daftarian PM; Stone GW; Kovalski L; Kumar M; Vosoughi A; Urbieta M; Blackwelder P; Dikici E; Serafini P; Duffort S; Boodoo R; Rodríguez-Cortés A; Lemmon V; Deo S; Alberola J; Perez VL; Daunert S; Ager AL
Fuente: J Infect Dis; 208(11): 1914-22, 2013 Dec 1.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Resumen: BACKGROUND: Amphotericin B (AmB), the most effective drug against leishmaniasis, has serious toxicity. As Leishmania species are obligate intracellular parasites of antigen presenting cells (APC), an immunopotentiating APC-specific AmB nanocarrier would be ideally suited to reduce the drug dosage and regimen requirements in leishmaniasis treatment. Here, we report a nanocarrier that results in effective treatment shortening of cutaneous leishmaniasis in a mouse model, while also enhancing L (mas)
11.

Evaluation of a prototype flow cytometry test for serodiagnosis of canine visceral leishmaniasis.

Autor(es): Ker HG; Coura-Vital W; Aguiar-Soares RD; Roatt BM; das Dores Moreira N; Carneiro CM; Machado EM; Teixeira-Carvalho A; Martins-Filho OA; Giunchetti RC; Araújo MS; Coelho EA; da Silveira-Lemos D; Reis AB
Fuente: Clin Vaccine Immunol; 20(12): 1792-8, 2013 Dec.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: Diagnosing canine visceral leishmaniasis (CVL) is a critical challenge since conventional immunoserological tests still present some deficiencies. The current study evaluated a prototype flow cytometry serology test, using antigens and fluorescent antibodies that had been stored for 1 year at 4°C, on a broad range of serum samples. Noninfected control dogs and Leishmania infantum-infected dogs were tested, and the prototype test showed excellent performance in differentiating these groups (mas)
12.

Cationic solid-lipid nanoparticles are as efficient as electroporation in DNA vaccination against visceral leishmaniasis in mice.

Autor(es): Saljoughian N; Zahedifard F; Doroud D; Doustdari F; Vasei M; Papadopoulou B; Rafati S
Fuente: Parasite Immunol; 35(12): 397-408, 2013 Dec.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: The use of an appropriate delivery system has recently emerged as a promising approach for the development of effective vaccination against visceral leishmaniasis (VL). Here, we compare two vaccine delivery systems, namely electroporation and cationic solid-lipid nanoparticle (cSLN) formulation, to administer a DNA vaccine harbouring the L. donovani A2 antigen along with L. infantum cysteine proteinases [CPA and CPB without its unusual C-terminal extension (CPB(-CTE) )] and evaluate their p (mas)
13.

Induction of protection against leishmaniasis in susceptible BALB/c mice using simple DOTAP cationic nanoliposomes containing soluble Leishmania antigen (SLA).

Autor(es): Firouzmand H; Badiee A; Khamesipour A; Heravi Shargh V; Alavizadeh SH; Abbasi A; Jaafari MR
Fuente: Acta Trop; 128(3): 528-35, 2013 Dec.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista; Research Support, Non-U.S. Gov't
Resumen: A suitable adjuvant and delivery system are needed to develop an effective vaccine against leishmaniasis. To induce a Th1 type of response and protection in BALB/c mice against Leishmania major infection, 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) nanoliposomes bearing an intrinsic adjuvanticity, were used as an antigen delivery system and immunoadjuvant for soluble Leishmania antigens (SLA). DOTAP liposomes containing different concentrations of SLA were prepared by using lipid film (mas)
14.

A comprehensive analysis of LACK (Leishmania homologue of receptors for activated C kinase) in the context of Visceral Leishmaniasis.

Autor(es): Sinha S; Kumar A; Sundaram S
Fuente: Bioinformation; 9(16): 832-7, 2013.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: The Leishmania homologue of activated C kinase (LACK) a known T cell epitope from soluble Leishmania antigens (SLA) that confers protection against Leishmania challenge. This antigen has been found to be highly conserved among Leishmania strains. LACK has been shown to be protective against L. donovani challenge. A comprehensive analysis of several LACK sequences was completed. The analysis shows a high level of conservation, lower variability and higher antigenicity in specific portions of (mas)
15.

Longitudinal analysis of serological tests officially adopted by the Brazilian Ministry of Health for the diagnosis of canine visceral leishmaniasis in dogs vaccinated with Leishmune®.

Autor(es): Marcondes M; de Lima VM; de Araújo Mde F; Hiramoto RM; Tolezano JE; Vieira RF; Biondo AW
Fuente: Vet Parasitol; 197(3-4): 649-52, 2013 Nov 8.
MEDLINE - Literatura Internacional en Ciencias de la Salud
Idioma: Inglés
: Artículo de Revista
Resumen: Development of vaccines against canine visceral leishmaniasis (CVL) may provide a prophylactic barrier, but antibody response detected by standard diagnostic techniques may not separate vaccinated from naturally infected dogs. Moreover, anti-Leishmania antibody levels in vaccinated dogs may be detectable for months. Accordingly, the aim of the present study was to comparatively evaluate an "in-house" ELISA with three serological tests officially adopted by the Brazilian Ministry of Health f (mas)
Resultados  1-15 de 1.750