Histopathological pattern of Orbito-Ocular Lesions, a retrospective hospital-based study spanning 15 years

Background: Many previous studies on orbito-ocular lesions are skewed in favour of the neoplastic lesions in general and the malignant lesions in particular. This, therefore, creates a vacuum on the spectrum of these lesions, thus may result in problematic diagnostic bias by the ophthalmologist and pathologist. Objective: To give the spectrum and relative frequencies of orbito-ocular biopsies and by extension orbito-ocular lesions/diseases at the University of Benin Teaching Hospital (UBTH). Materials and Methods: A retrospective descriptive study of all cases of orbito-ocular biopsies with histopathologic diagnosis. Results: There were 236 orbito-ocular biopsies. The male to female ratio was slightly in favour of the females. Orbito-ocular biopsies had a wide age range that spanned from the 1st to 10th decade, mean age in the 3rd decade (20-29years) and a peak age in the 1st decade (0-9 years). The neoplastic lesions were the prevalent indication for orbito-ocular biopsies (63.72%) while the conjunctiva (58.10%) was the most common site for orbito-ocular biopsies. Conclusion: This study noted a wide array of orbito-ocular lesions for which biopsies were done for histopathological diagnosis. This we hope will in no small measure increase the diagnostic precision of the ophthalmologist and the pathologists in our own environment

Ocularhaemodynamics Parameters of Asymptomatic HAART Experienced HIV-Infected Under-Five Children

Objectives: Study aimed at evaluating the impacts of HAART on retinal blood flow of a symptomatic HAART - experienced HIV-infected underfive children. Method: Ethical approval and patient consents were obtained before commencement of the study in the selected hospitals. Thirty asymptomatic HAARTexperienced HIV-infected children and three seronegative children aged 0-5 year-old fulfilled conditions for ocular ultrasonography among 60 convenience sampled under-fives. Ocular ultrasonography was done on the patients in supine position with eyes closed as instructed by the radiologist. Maximum velocity (Vmax); pulsatility index (PI); resistive index (RI); optic nerve diameter; lens thickness and axial diameter were measured. Results of HAART-experienced children were not compared with the control children because of unequal size. Data were analysed by using ANOVA and level of significance was considered at p0.05. Results: Vmax of blood flow in central retinal artery (CRA) of asymptomatic HAART - experienced HIV infected children was 12.2cm/s while that of seronegative children was 13.4 cm/s. The PI and RI of blood flow in CRA of asymptomatic HAARTexperienced HIV-infected children were 0.8 and 0.5 respectively while those of the seronegative children were 0.6 and 0.4 respectively. Reduced Vmax of blood flow of CRA was significantly associated with both increased PI and RI of asymptomatic HAARTexperienced HIV-infected underfive children.Discussion: Vmax of CRA of asymptomatic HAART-experienced HIV-infected children was reduced because of their increased PI and RI suggesting an increased resistance to blood flow in asymptomatic HAART experienced HIVinfected children.Conclusion: Reduced Vmax of blood flow to CRA was significantly associated with increased PI and RI of asymptomatic HAARTexperienced HIV-infected children