Childhood Inflammatory Bowel Disease in Libya: Epidemiological and Clinical Features

Background et Aims: Inflammatory bowel disease is thought to be rare in Libya. The aim is to determine the prevalence of juvenile onset inflammatory bowel disease in Libya. Setting: Al-Fateh childrens' hospital; Benghazi; Libya. Methods: This is a retrospective study of all cases diagnosed over 10 years (1997-2006) with either ulcerative colitis; Crohn's disease or indeterminate colitis. Inclusion criteria were age 15 years at time of presentation who were resident in the eastern part of the country and who diagnosed with inflammatory bowel disease. Clinical features were outlined using a proforma. Results: Sixteen cases were diagnosed with inflammatory bowel disease; of whom 11 were males (M:F ratio of 1.5:1). The prevalence and incidence rates in the year 2006 were 3.6 and 0.9 per 100;000 children; respectively. The incidence rate increased from 0.2 in 2002 to 0.9 in 2006 (Z score of 39.87; p); abdominal pain; anorexia and weight loss in 9 (56.2); anemia in 7 (43.75) and vomiting in 6 (37). Ileopancolitis was found in 3 patients whereas 6 patients had ileocecal disease. Conclusions: Childhood inflammatory bowel disease in this population is not so rare and it is increasing. The clinical pattern is similar to that reported by others

Les infections au cours des maladies inflammatoires chroniques de l'instestin

Pre-requis:les infections sont frequentes au cours des maladies inflammatoires chroniques de l'intestin.Elles sont associees a un risque eleve de mortalite.But:preciser les differentes infections survenants chez les malades atteints des maladies Crohn et de rectocolite hemorragique et leurs moyens de preventions .Materiel et methodes: revue de la litterature .Resultats: les infections survenant au cours des poussees peuvent expliquer la resistance aux traitements de la maladie. Il s'agit le plus souvent des infections a clostridium difficile et a cytomegalovirus.Les infections a Epstein -Barr virus majorent le risque de lymphomes chez les malades sous azathioprine. Les infections opportunistes sont relativement frequentes au cours des maladies inflammatoires chroniques de l'intestin; en particulier en cas de prise d'un ou de plusieurs immunosuppresseurs. prevention de ces infections opportunistes se base sur un bilan pre-therapeutique complet; les vaccinations chez les patients immunodeprimes et la chimioprophylaxie dans certaines situations .Conclusion: la connaissance des differentes infections pouvant survenir chez les malades attientes de maladies inflammatoires chroniques de l'intestin est primordiale.Le traitement de ces infections est associees a une meilleures reponse aux traitements de la maladie et a une reduction de la mortalite en cas d'infection opportuniste

Maladie de Crohn: premiere description en Cote-d'Ivoire

The authors rep o rt the fi rst case of Crohn's disease in Cote-d'Ivo i re. A 20-ye a r-old Ivo rian man presented chronicdiarrhea and weight loss over six ye a rs. Ulcerated lesions we re found throughout the colon extending to the terminal ilieum but not involving the rectum. Diagnosis of Crohn's disease was established on ra d i o l ogical and histological findings. Treatmentconsisted of total colectomy with ileorectal anastomosis. This case is of special interest because of the extremely low incidence of Crohn's disease in black Africa