Pharmacodynamic effects of cimetidine metronidazole on the blood glucose lowering glyburide in rats

The effects of the two imidazole derivatives (cimetidine and metronidazole) on the control of blood glucose level by Glyburide were determined in normal and hyperglycemic rats. Both imidazole derivatives insignificantly reduced the blood glucose lowering ability of glyburide in both normal and hyperglycemic rats after a single dose administration. However; on the chronic administrations for 3 weeks; there were no observed significant variations in blood glucose levels of all the treated rats. Although the drugs did not significantly affect the control of blood glucose levels by glyburide; precautions must be taken when the need to co administer these drugs arises especially in a prolonged therapy situation