Formulation and Physical Characterization of Ibuprofen-DEAE-Dextran Nanoconjugates via Surfactant Solubilization

Background: The optimization of polymer-drug conjugate design is important in effective and efficient delivery of poorly soluble drugs. Objectives: This work focuses on the formulation of novel amorphous ibuprofen-polymer nanoconjugates based on the polymer-drug complexation in order to improve its physical characteristics in the absence of toxic organic solvents. Methods: Amorphous Ibuprofen - DEAE-Dextran nanoconjugates were prepared using surfactant solubilization method. Physical characterization of the nanoconjugates was carried out via conductivity; surface tension; viscosity; transmittance/turbidity; particle size measurement; zeta potential; conjugation efficiency and Scanning Electron Microscopy (SEM) techniques. Results: A remarkably high loading capacity was achieved ranging from 89.05 to 96.34%. The conductivity measurements showed that the critical association concentration (cac) was exhibited at 2.34 mg/mL and critical micellar concentration (cmc) at 8.0 mg/mL. The presence of DEAE-Dextran decreased the cac of ibuprofen significantly (p 0.05; n

L'association paracetamol+ibuprofene est-elle preferable au paracetamol seul ou a l'ibuprofene seul pour le traitement de la fievre chez les enfants?

Il apparait de plus en plus sur le marche burkinabe des medicaments; des associations de substances d'indication similaire; et dont l'interet therapeutique reste a demontrer. Ces associations contribuent-elles a un usage rationnel des medicaments? Faut-il continuer a homologuer ces associations ? Nous presentons ici les resultats d'une etude sur l'association paracetamol+ibuprofene dans la fievre chez les enfants

Mieux prescrire l'ibuprofene

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