A cliniccopathologic correlation study of 2396 histopathologic skin biopsy specimens

Clinicopathologic correlation of skin biopsies is relevant in a dermatology patient's management. The study aimed to conduct a clinicopathologic corellation of skin samples. Methods: Retrospective cross-sectional analysis of 2,396 skin biopsy specimens submitted between January 2015 and December 2021. Clinicopathologic correlation was done on only samples which had definitive clinical and histopathologic diagnosis. Data was analyzed with the R studio. Results: A total number of 2,396 skin biopsies were received from 2319 patients. Clinicopathologic correlation was conducted on 1,831 samples which had both definitive clinical and histopathological diagnoses. A definitive clinicopathologic correlation was obtained in 66.8% (1224/1831) and this was 64.8% for benign tumours, 60.4% for malignant tumours, 66.7% for inflammatory diseases, 70.8% for infections, 85.5% for scalp and hair disorders and 50% for dermal deposits. Conclusion: Clinicopathologic correlation of skin biopsies is high. Correlation is better with inflammatory diseases compared to neoplastic diseases

Aspects épidémiologiques et cliniques des brûlures cutanées graves en milieu hospitalier en Côte d'Ivoire / Epidemiological and Clinical Aspects of severe Cutaneous Burns in Hospital in Cote d'Ivoire

Contexte et Objectif. Les brûlures cutanées graves constituent un véritable problème de santé publique à l'échelle mondiale. L'objectif de cette étude était de décrire le profi l épidémiologique et clinique des brûlures cutanées graves dans le but de mettre en place de mesures préventives effi cientes. Méthodes. Ils'agissait d'une étude transversale rétrospective à visée descriptive et analytique déroulée sur une période de 3 ans au sein du service de Dermatologie du CHU de Bouaké. Tous les malades quelque soit l'âge et le sexe reçus au service dermatologie pour brûlure cutanée grave ont été inclus. Les tests statistiques utilisés étaient les tests de Kruskal Wallis (KW) et de Mann whitney-Wilcoxon(MWW) Résultats. Sur la période d'étude, nous avons inclus 46 patients sur 6074 admissions soit une prévalence hospitalière de 0,75%. L'âge moyen était de 20,79 ans. Le sex-ratio était de3,18. 10,9% de nos patients avaient une condition socio-économique défavorable. Les antécédents les plus retrouvés étaient l'épilepsie (6,5%) et les troubles psychiatriques (4,3%). Les brûlures thermiques étaient majoritaires(95,7%), etles brûlures par fl amme (56,8%) et l'ébouillantement (43,2%)en constituaient les principales causes.Les membres étaient plus atteints (93,5%).Les brûlures étaient du premier degré (10,9%) et du deuxième degré (89,1%). L'étendue moyenne de la brûlure était de 23,91%. Les sujets d'âge plus jeunes étaient surtout brûlés par les liquides chauds. Il n'y'avait pas de lien entre l'âge et l'étendue des lésions ni entre l'agent causal et l'étendue des lésions. Conclusion. Les brûlures cutanées graves représentent un fl éau en Côte d'ivoire.Il est indispensable d'instaurer des mesures de prévention en vue de limiter les conséquences de celles-ci.

Dermal exposure and changes in skin barrier function of base metal refinery workers co-exposed to cobalt and nickel

Refinery workers are exposed to many metals; including cobalt and nickel; both of which are skin sensitisers; causing allergic contact dermatitis. Dermal exposure; and changes in skin barrier function [skin hydration; transepidermal water loss (TEWL) and skin surface pH] from start to end of shift; of base metal refi nery workers co-exposed to cobalt and nickel; were assessed. Changes in SH were inconsistent; while TEWL generally increased and SS-pH decreased. The decrease in SS-pH is most likely due to direct skin contact with sulphuric acid. Dermal exposure was variable even though workers wore personal protective gloves; highlighting the limitations of personal protective clothing in controlling exposure. None of the workers presented with allergic contact dermatitis (ACD). The small sample size of this study limits the interpretation of the absence of ACD; but the healthy worker effect and ethnic differences in skin structure and function may be contributing factors

Dermatophytes and other Skin Mycoses Found in Featherless Broiler Toe Webs

Background: Feartherless broilers which are produced by a complex breeding programme from feathered parents carrying the Sc-gene; dissipates excessive body heat under hot and humid conditions. It has high body weight; and grows very rapidly when compared with standard commercial broilers. Their toe webs are bigger than standard commercial broilers; and could harbor fungi which can cause infections where there is the opportunity. Objectives: To isolate and identify the presence of fungi in toe webs of featherless broilers. Methods: A total of 50 featherless broilers' toe webs samples were examined microscopically for the presence of fungi. The samples were examined microscopically and culturally using standard microbiological techniques. Results: The fungi recovered were as follows. Microsporum gypseum 9 (22); Trichophyton mentagrophytes var. mentagrophytes 5 (12); Microsporum gallinae 3 (7); Aspergilus flavus 10 (24); Fusarium sp 6 (15); Alternaria alternata 3 (7) Scopulariopsis brevicaulis 2 (5) and Candida albicans 3 (7); Conclusion: The featherless broilers' toe webs habour fungi which cause mycotic skin disease and cannot be regarded as ordinary normal flora of toe webs

Dermal exposure sampling methods: an overview

Although a total of 174 and 117 substances have been listed with a skin (Sk) notation in the Regulations for Hazardous Chemical Substances and Regulation 22.9 of the Mine Health and Safety Act respectively; dermal sampling is not used frequently to assess exposure to these substances. A variety of measurement methods and strategies have been developed during the past forty years to assess dermal exposure. These methods include interception methods (also referred to as surrogate skin methods); removal of contaminant (substance) methods and in situ detection methods (also referred to as fluorescent tracer methods). The aim of this paper is to give an overview of the different dermal sampling methods. Furthermore; the applicability of each method for sampling different hazardous chemical substances will be highlighted in order to assist Occupational Hygienists in choosing the correct dermal sampling method

Complications de la depigmentation cosmetique en Afrique

L'utilisation a visee cosmetique de produits depigmentants ou eclaircissants est une pratique frequente dans certains pays africains sub-sahariens. L'application prolongee de certains composants pharmacologiques (hydroquinone; dermocorticoides; mercure) peut entrainer des complications cutanees (dyschromie; ochronose exogene; acne et hypertrichose; vergetures; mycoses; pyodermites; erysipele; gale; dermite de contact.) ou des effets adverses systemiques (hypertension; hypercorticisme ou insuffisance surrenalienne; nephropathie mercurielle.)

Skin lightening products - specification

It provides the expected requirements of such products and for establishing acceptable levels for reactive ingredients; toxic metals; instruction for and limitations of use; warning; labelling and packaging