Carotid doppler ultrasonography in patients with co-existing type 2 diabetes mellitus and hypertension in Nigeria

Background:The co-existence of diabetes mellitus (DM) and hypertension (HTN) has been rising globally with subclinical atherosclerotic complications. These vascular changes can be detected using carotid ultrasonography. Objectives: To determine and compare the carotid arterial structural wall changes and blood flow velocities of adults with co-existing DM and HTN with age-and sex-matched non-diabetic, non-hypertensive controls. Methods: A cross-sectional comparative study of 300 participants comprising 200 adults with co-existing DM and HTN and 100 age-and sex-matched controls was done. Their carotid arteries were examined bilaterally for plaques, carotid intima media thickness (CIMT) and flow velocities ­peak systolic velocity (PSV), end diastolic velocity (EDV), pulsatility index (PI) and resistive index (RI) using 4­12MHz linear array transducer. Visceral obesity and serum lipids were also assessed. Results: The mean age of the subjects was 56.13 ± 6.93 years; they comprised 38% males and 62% females. The subjects' CIMT was statistically significantly higher (p = 0.001) with a three-fold mean increase (45.5%) compared to the controls (13.7%). Lower flow velocities but higher indices were also observed in the subjects. Strong and significant correlations were observed between EDV and PI r =-0.663, p=>0.001), EDV and RI (r = -0.661, p=>0.001) and PI and RI (r =0.988, p= >0.001)among the subjects. Conclusion: Significant reduction in flow velocities with increased CIMT may be an early indication of subclinical atherosclerosis. Therefore, carotid ultrasonography should be mandatory in individuals at risk for early detection and possible prevention of atherosclerotic complications.

Faible performances diagnostiques de l'IPS cheville de repos par rapport au doppler artériel des membres inférieurs dans le diagnostic de l'AOMI chez le patient coronarien: à propos d'une série hospitalière / Weak diagnostic performance of resting ankle ABI compared with lower limb's arterial Doppler in the diagnosis of PAD in coronary patients: about a hospital serial study

Introduction. L'index de pression systolique (IPS) est considéré comme un outil indispensable, pour la prise en charge de l'artériopathie oblitérante des membres inférieurs (AOMI), cependant un complément d'exploration par les autres testes physiologiques, IPS au gros orteil et IPS effort s'impose afin de réduire le nombre des faux négatifs. Objectif. Démontrer le faible apport de l'IPS cheville de repos par rapport à l'échodoppler artériel des membres inférieurs dans le diagnostic de l'AOMI. Matériels et méthodes. Sur une série de 300 malades coronariens consécutifs durant l'année 2016 hospitalisés dans le service de cardiologie de l'hôpital universitaire de Constantine, un dépistage de l'AOMI a été réalisé par les investigations suivantes : Mesure de l'IPS à la cheville, compléter par la mesure de l'IPS a l'orteil si incompressibilité artérielle et par la mesure de l'IPS d'effort si l'IPS de repos est limite. Un échodoppler artériel des membres inférieurs a été réalisée par un échographe vividE9 General Electric pour l'ensemble de nos malades, en utilisant une sonde à balayage linéaire 12L, destinée à l'exploration vasculaire périphérique permettant d'obtenir un dépistage ciblé, Le traitement et l'exploitation des données ont fait appel au logiciel SPSS22. Résultats. Une sensibilité modérée de l'ordre de 50%, face à une spécificité élevée avoisinant 100% de l'IPS cheville de repos par rapport à l'échodoppler artériel des membres inférieurs. Sensibilité nettement améliorer après complément par les autres testes physiologiques qui sont la prise de l'IPS cheville effort et la mesure de l'index de pression systolique au gros orteil. Conclusion. L'examen vasculaire des membres inférieurs associe à la mesure de l'IPS cheville couplée aux autres testes physiologique (IPS au gros orteil et IPS effort) assurent une bonne sensibilité et spécificité diagnostiques de l'AOMI

Characterisation of left ventricular function by tissue Doppler imaging technique in newly diagnosed, untreated hypertensive subjects

BACKGROUND:Hypertension results in structural and functional changes in the heart. Early detection of abnormalities of cardiac structure and function is important in the assessment and treatment of hypertensive subjects. The aim of this study was to evaluate the utility of the tissue Doppler echocardiographic technique in characterising diastolic and systolic functions in untreated native black African hypertensive subjects.MATERIALS AND METHODS:Forty consecutive, newly diagnosed, untreated hypertensives with adequate conventional echocardiographic (2-D, M-mode, transmitral and pulmonary Doppler flow velocities) and tissue Doppler echocardiographic images were recruited into the study. The control subjects were apparently normal individuals. Each arm of the study consisted of 21 male and 19 female subjects.RESULTS:The two groups were comparable by age (48.6 +/- 11.35 years in the hypertensives vs 48.1 +/- 11.33 years in the controls; p = 0.844) and gender distribution (M/F: 21/19 in both groups). Other baseline characteristics, except for blood pressure parameters, which were predictably higher in the hypertensive subjects, were comparable between the two groups. The hypertensive subjects had a lower systolic myocardial velocity (Sm) and early diastolic myocardial velocity (Em) in comparison with the controls (p = 0.033 and p = 0.018, respectively). The late diastolic myocardial velocity (Am) was comparable in the two groups (p = 0.430). CONCLUSIONS:Tissue Doppler echocardiography demonstrates diastolic dysfunction relatively early in native African hypertensives and may be useful for detecting subtle deterioration in systolic function