Effect of HIV-1 Infection on Malaria Treatment outcome in Ugandan Patients
Afr. health sci. (Online)
; 7(2): 86-92, 2007.
Artigo
em Inglês
| AIM
| ID: biblio-1256473
Biblioteca responsável:
CG1.1
ABSTRACT
Background:
Malaria and HIV-1 infection cause significant morbidity and mortality in sub-Saharan Africa. HIV-1 increases risk for malaria with the risk increasing as immunity declines.The effect of HIV-1 infection on antimalarial treatment outcome is still inconclusive.Objective:
To compare antimalarial treatment outcome among HIV-1 positive and negative patients with acute uncomplicated falciparum malaria treated with chloroquine plus sulfadoxine-pyrimethamine (CQ+SP).Methods:
Ninety eight HIV-1 positive patients aged 18 months or older with acute uncomplicated falciparum malaria were treated with CQ+SP and followed for 28 days to monitor outcome.Treatment outcome of HIV-1 positive patients was compared to that of 193 HIV-1 negative historical controls.The primary study outcome for both groups was treatment failure.Results:
HIV-1 positive patients older than 5 years of age were less likely to have treatment failure compared to HIV-1 negative patients in the same age group (RR 0.59 95CI 0.4- 0.8; p a 0.001) and HIV-1 positive patients on routine cotrimoxazole prophylaxis were less likely to have treatment failure following CQ+SP treatment compared to HIV negative patients (RR 0.6 95CI 0.43-0.92; p = 0.006).There was no difference in treatment outcome according to HIV-1 status for children younger than 5 years of age.Conclusions:
Adherence to cotrimo-xazole prophylaxis should be reinforced in HIV positive patients and it should be reassessed if these patients present with acute episodes of malaria
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Infecções por HIV
/
Resultado do Tratamento
/
Malária
Idioma:
Inglês
Revista:
Afr. health sci. (Online)
Ano de publicação:
2007
Tipo de documento:
Artigo
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