Oxidative stress markers and disease severity among children with sickle cell anaemia
Ann. Health Res. (Onabanjo Univ. Teach. Hosp.)
; 5(2): 193-202, 2019. ilus
Artigo
em Inglês
| AIM
| ID: biblio-1258819
Biblioteca responsável:
CG1.1
ABSTRACT
Background:
Sickle cell anaemia has been associated with oxidative stress. Total Antioxidant Capacity (TAC), Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) are cumulative markers of oxidative stress.Objective:
To evaluate the serum levels of oxidative stress markers in children with sickle cell anaemia (SCA) and determine the relationship between these markers and disease severity.Method:
One hundred and fifty-six children, comprising 78 with SCA, aged 1 - 15 years and 78 age- and sex-matched Haemoglobin AA controls were studied. Serum TOS, OSI, and TAC were determined using ELISA kits. The severity of the SCA was determined using clinical and laboratory parameters.Result:
Children with SCA had lower mean serum TAC (0.83±0.31UAE) than controls (1.19±0.24UAE) with p< 0.001) but positive correlation with TOS (r = 0.3, p = 0.008) and OSI (r = 0.6, p < 0.001).Conclusion:
Children with SCA had lower TAC but higher TOS and OSI than matched controls. Oxidative stress markers had a significant relationship with SCD severity
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Ácido Ascórbico
/
Estresse Oxidativo
/
Anemia Falciforme
/
Nigéria
/
Antioxidantes
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Ann. Health Res. (Onabanjo Univ. Teach. Hosp.)
Ano de publicação:
2019
Tipo de documento:
Artigo
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