Serum Resistin Levels in Nonalcoholic Fatty Liver Disease and their Relationship to Severity of Liver Disease
JEMDSA (Online)
; 15(1): 53-56, 2010.
Article
em En
| AIM
| ID: biblio-1263741
Biblioteca responsável:
CG1.1
ABSTRACT
Background:
Resistin is a hormone that is linked to the development of insulin resistance (IR); but information on the direct relationship of resistin levels in humans with nonalcoholic fatty liver disease (NAFLD); and their effect on the histological severity of NAFLD; is lacking.Objective:
The aim of the current study is to determine the circulating resistin levels obtained from patients with NAFLD and to correlate them with insulin resistance and hepatic histological features.Methods:
Blood samples were collected from 30 consecutive patients with liver-biopsy-proven NAFLD and 30 subjects as controls. Serum resistin levels were measured. Body mass index (BMI) was calculated for all subjects; and serum insulin; C-peptide; and lipoprotein levels were also measured.Results:
Mean serum resistin level and BMI in the NAFLD group were significantly higher than in the controls (both P 0.001). Both men and women in the NAFLD group had higher mean serum resistin levels than did the men and women in the control group (all P 0.001). Multivariate analysis showed that the percentage of hepatic steatosis; sex; BMI; and homeostasis model assessment of insulin resistance [HOMA(IR)] were related to serum resistin levels.Conclusion:
These data suggest increased resistin levels in NAFLD patients which are related to histological severity of the disease. These findings support the link between resistin; insulin resistance and BMI in these patients
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Assunto principal:
Resistência à Insulina
/
Resistina
/
Alcoólicos
/
Hepatopatias
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
JEMDSA (Online)
Ano de publicação:
2010
Tipo de documento:
Article