Efficacy of quinine for falciparum malaria according to previous chloroquine exposure. [short report]

ABSTRACT

Chloroquine has been reported to antagonize the anti-parasitic action of quinine against Plasmodium falciparum in vitro. The authors looked for evidence of any such antagonism in vivo. In 123 Malawian children with cerebral malaria treated with parenteral quinine; the likelihood of survival and the rate of recovery were much the same in patients who had taken chloroquine and those who had not. In these circumstances there was no evidence of chloroquine/quinine antagonism