Studies and evaluation of compressed microspheres
Libyan International Medical University Journal
; 1(1): 6-16, 2016. tab
Artigo
em Inglês
| AIM
| ID: biblio-1264998
Biblioteca responsável:
CG1.1
ABSTRACT
This work was aimed at the use of dissolution testing and similarity factor to assess the level of damage taken by active drug microspheres during compression in tablet dosage form. To achieve that, combinations of suitable excipients were used to protect drug microspheres during compression. The excipients were used in the form of powders, granules or placebo pellets prepared by extrusion-spheronization technology. The excipients were evaluated alone, in combinations and post-compression into compacts. Preliminary experiments included density, hardness, friability and disintegration on all of the selected excipients. Based on such experiments it was found that the flowability of combination powders was more acceptable than individual excipients. Two combinations of microcrystalline -starch and microcrystalline cellulose -calcium carbonate granules were selected to be compressed with active ketoprofen pellets. In all the combinations used there was a significant amount of damage to drug pellets. The kinetics of drug release appears to follow the zero-order rate and the rate remained unchanged even when a significant degree of damage to pellets occur. It was found that a high level of excipients is required in order to prepare microspheres as a rapid disintegrating tablet
Texto completo:
DisponíveL
Índice:
AIM (África)
Assunto principal:
Farmacocinética
/
Liberação Controlada de Fármacos
/
Líbia
/
Microesferas
Tipo de estudo:
Ensaio Clínico Controlado
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Libyan International Medical University Journal
Ano de publicação:
2016
Tipo de documento:
Artigo
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