Towards 2030 target for hepatitis B and C viruses elimination: assessing the validity of predonation rapid diagnostic tests versus enzyme-linked immunosorbent assay in state hospitals in Kaduna, Nigeria
Niger. med. j. (Online)
; 60(3): 161-164, 2019. tab
Artigo
em Inglês
| AIM
| ID: biblio-1267651
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CG1.1
ABSTRACT
ntroduction Sub-Saharan Africa accounts for 25% of the estimated global 325 million people with chronic hepatitis B and C virus infections. Weak blood transfusion systems facilitate the spread of both hepatitis B and C virus infections. This is worsened by the absence of sustainable quality assurance programs and perennial shortage of sensitive screening kits. We aim to compare the validity of rapid diagnostic tests (RDTs) with the World Health Organization-recommended quality-assured enzyme-linked immunosorbent assay (ELISA) screening method for these viruses. Materials and Methods:
We conducted a cross-sectional study on consecutive blood donor samples. Two hundred and sixty-four blood donor samples screened for hepatitis B and C viruses using RDTs were retested at a National blood transfusion service, Kaduna, Nigeria. Data were analyzed using OpenEpi version 3.01 to determine the sensitivity, specificity, and predictive values of RDTs versus ELISA.Results:
The sensitivities of the RDTs at 95% confidence interval (CI) were low 40% (19.864.3) and 50.0% (18.881.2) for hepatitis B surface antigen (HBsAg) and hepatitis C virus (HCV) antibody, respectively. The specificities and 95% CI were high 99.9% (97.899.9) and 100.0% (98.5100) for HBsAg and HCV antibody, respectively.Conclusion:
Predonation RDTs screening of blood donor samples for hepatitis B virus and HCV in hospital donation units performed poorly compared to quality-assured ELISA screening in Kaduna. The risk of transmitting viral hepatitis through blood transfusion still exists. We recommend quality-assured ELISA screening of all donated units for HBsAg and HCV antibody to reduce the risk of these transfusion-transmitted infections
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Índice:
AIM (África)
Assunto principal:
Doadores de Sangue
/
Testes Diagnósticos de Rotina
/
Nigéria
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Niger. med. j. (Online)
Ano de publicação:
2019
Tipo de documento:
Artigo
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