Leber plus disease

ABSTRACT

Introduction: Leber's neuropathy is a rare disease. The ''Leber Plus' is exceptional; is associated with a severe neurological disorder. This presentation was intended to describe a case of Leber Plus. Methods: A 45-year-old man consulted our department for bilateral blindness since 15 years Results: On both sides there was no light perception; optic atrophy with serious peripapillary vessels sclerosis. There was a flccid paraplegia. The 11 778 mitochondrial DNA mutation was identifid. Conclusion: The prevalence of the Leber's neuropathy is probably underestimated in black Africa because of lack of molecular biology laboratory