Treatment Outcomes in Patients Receiving Combination Antiretroviral Therapy in Central Hospital; Benin City; Nigeria
Trop. j. pharm. res. (Online)
; 9(1): 1-10, 2010. tab
Artigo
em Inglês
| AIM
| ID: biblio-1273126
Biblioteca responsável:
CG1.1
ABSTRACT
Purpose:
This study investigated mortality rate; early CD4 responses; pattern of ARVs substitutions and medication adherence of HIV-infected patients on first-line triple combination antiretroviral therapy (ART) in Central Hospital; Benin City; Nigeria.Methods:
A retrospective assessment of 196 HIV-infected patients on first-line combination ART regimens was performed following 18 months of therapy. Medication adherence assessment of a 69-patient follow-up target group was based on a study-specific questionnaire. Paired sample t-test and simple linear correlation were used to test the association of the CD4-cell counts at different time intervals. Kaplan-Meier model was used to assess survival functions while log-rank test was applied to assess statistical difference at 95confidence interval (CI). Mean age of participants was 33.6 years (95CI; 32.1 - 35.2; 67.9were females.Results:
At ART initiation; 27.0were at WHO clinical stage II; 47.0at stage III. Mortality rate (N = 196) was 20.3 deaths per 100 patient-months; 31.6occurred in 30 days while 52.6occurred post-120 days of treatment. The mean CD4-cell count (cells/mm3) at ART initiation was 179.2 which increased to 328.5 at 3 months; 325.6 at 6 months; 357.4 at 12 months; and 366.7 at 18 months; (p 0.01). Patients started on stavudine-based or efavirenz-based regimens were considerably more likely to have that drug substituted; compared to patients started on zidovudine-based or nevirapine-based regimens. The level of adherence reported after 18 months on ART was 73.8.Conclusion:
In this setting; patients receiving ART showed significant improvements in CD4-cell status but adherence level was relatively poor. Patients were more stable on zidovudine-based or nevirapine-based regimens than on stavudine-based or efavirenz-based regimens. Early mortality rate was high; indicating a need for earlyinterventions:
Texto completo:
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Índice:
AIM (África)
Assunto principal:
Síndrome
/
Resultado do Tratamento
/
Tratamento Farmacológico
/
Adesão à Medicação
Idioma:
Inglês
Revista:
Trop. j. pharm. res. (Online)
Ano de publicação:
2010
Tipo de documento:
Artigo
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