ABSTRACT
The antiviral activity of extracts obtained from Ageratina havanensis (Kunth) R.M.King & H.Rob., Asteraceae, against rabbit vesivirus (RaV) (Caliciviridae) and human herpes simplex viruses type 1 and 2 (HSV-1, HSV-2) (Herpesviridae) were analyzed, and the main metabolites from the most active extract were isolated and characterized. The antiviral properties were investigated by measuring the inhibition of viral-induced cytopathic effect in Vero cells. The strongest inhibitory effects were found for ethyl acetate extract from leaves (SI=5 for RaV and SI=5.4 for HSV-1). The crude ethyl acetate extract was further fractionated by chromatographic methods and the structures of isolated compounds were established through comprehensive spectroscopic analyses, including IR, 2D NMR and MS. Four flavonoids were identified: 5,4'-dihydroxy-7-methoxyflavanone (sakuranetin), 3,5,4'-trihydroxy-7-methoxyflavanone (7-methoxyaromadendrin), 4'-O-β-D-glucosyl-5,3'-dihydroxy-7-methoxyflavanone (4'-O-β-D-glucosyl-7-methoxy-eriodictyol) and 4'-O-β-D-glucosyl-5-hydroxy-7-methoxyflavanone (4'-O-β-D-glucosylsakuranetin). This is the first report on antiviral activity for Ageratina havanensis.
ABSTRACT
Se analizan 3 pacientes con alteraciones dentoesqueletales que acudieron a los servicios multidisciplinarios y que en su infancia recibieron tratamiento ortodontico convencional con aparatologia fija. Se muestra como en ocasiones la correccion dentaria no satisface la espectativa del paciente con relacion de la alteraciones esqueletales que influyen en la forma de la cara
Subject(s)
Humans , Female , Adult , Mouth Abnormalities/therapy , Evaluation of Results of Therapeutic Interventions , Jaw Abnormalities/therapy , Orthodontics, Corrective/adverse effectsABSTRACT
Se presenta el caso de un paciente con una miasis bucal posterior al tratamiento quirúrgico de una fisura labiopalatina.El cuadro clínico del caso se caracterizó por dolor bucal, prurito, halitosis de gran fetidez con gran tumefacción del suelo de la boca y regiones submaxilares con disfagia en la región palatina y abundantes larvas. Se observó una rápida recuperación posterior a la aplicación de miasis cutánea