ABSTRACT
Background: Smoking is significant risk factor for further kidney failure. Haroun et al. found that current smoking was associated with HR of 2.6 for future RRT and having kidney disease listed on the death certificate compared with the former and never smokers [2]. Regarding smoking and kidney pathophysiology, direct vascular effects are probably a major mechanism [3-5]. Smoking is a particularly associated with atherosclerosis. The purpose of this study was to determine the effects of smoking on renal function and arterial stiffness in the CKD patients. Methods: A cross-sectional study was conducted in which adolescents aged 20 to 60 years with CKD total 125 patients with non diabetic CKD (mean age 40.30±10.82) were recruited. CKD was evaluated by the eGFR using the Cockcroft-Gault formula. Cardio-Ankle vascular index (CAVI) was determined as an index of arterial stiffness.Results: Even though there wasn’t an age difference between the smoking and non smoking groups, the renal function (38.1±22.6 vs. 90.5±59.9, p<0.0001) among smokers decreased comparing to the non smokers. The Pearson’s correlation analysis indicated that the smoking index was significantly correlated with the renal function (r=-0.392, p=0.02) and the arterial stiffness (r=0.573, p<0.0001).Conclusion: We found that smoking influenced on renal, it is a significant risk factor of CKD.