ABSTRACT
The vast potential of plants has bioactive compounds that could be effective or inhibitory to microorganisms. Several experiments aimed at understanding the plant composition and its safe usage in the modern world have been conducted due to their traditional importance in herbal medicine. Psidiumsppis a phyto-therapeutic plant believed to have active components that helps to manage and/ or treat different disease conditions such as vomiting, fever, diarrhea, dysentery, ulcer etc. Thus, understanding of the antimicrobial nature via research on their extracts will further explain their role in the history of herbal medicine and application in modern world. After application of inclusion and exclusion criteria, a systematic review composed of sixteen published research articles of twenty trials from different parts of Psidiumspp extract against Escherichia coli and Staphylococcus aureus were appraised. The outcome was evaluated via zones of inhibition with consideration to the extraction solvent and the plant part. Analysis of the available data showed that the choice of solvent [95% C.I] affected the amount of composition extracted in the order of methanol, aqueous, acetone and ethanol while the plants part also varied in terms of their bioactive properties to inhibit the target organism in order of leaf, fruit, stem bark, twig and seed. Due to the ability of these extracts to inhibit the target organisms, it can therefore be deduced that concentration of the active components of Psidiumspp can be used as an alternative to treat diseases related to E. coli and S.aureus