ABSTRACT
The presence of estrogen and progesterone receptors evaluated in intra cranial vestibular schwanoma. Material and method: In this study 31 patients with acoustic neuroma operated between 1994 and 2001 in Ghaem Hospital were studied retrospectively. The paraffined biopsies were evaluated for presence of the estrogen and progesterone receptors by immunohistochemical assays. Medical records were reviewed for demographic characteristics of the patients, their clinical manifestations, location of tumors, surgical removal, and the size of tumors. there were 18 [58.1%] women and 13 [41.9%] men with average age 40.9 years. The most common clinical manifestation was hearing impairment [25 cases]. In eleven patients [35.5%] acoustic neuroma was in the right cerebellopontine angle [CPA], in 19 [61.3%] in left, and one patient with neurofibromatosis type II had bilateral vestibular schwanoma. Eighteen patients [58.1%] had progesterone receptors were detected. There was no relation between the patients characteristics [sex, age, and location of tumor] and the presence of the estrogen receptors of progesterone and estrogen receptors [p=0.524, p= 1.102, p= 0.526 respectively] and the progesterone receptors [p=0.739, p= 0.253, p= 0.466 respectively]. since the receptors of progesterone and estrogen were found in significant numbers in our patients, we suggest further studies on the role of these receptors in this tumor and their probable importance in treatment acoustic neuroma