[Effect of exercise with moderate intensity in the morning on some factors of immune systems in adults]

The purpose of this study was to determine changes in salivary immunoglobulin A concentrations [S-IgA] and cortisol levels and any relationship between them, in adults after eight weeks of moderately intense exercise in the morning. Thirty, healthy, adult men [aged 30-50 years] having a sedentary lifestyles, were randomly selected and assigned to either the control or the exercise group; their exercise program consisted of three sessions a week, for eight weeks. Each subject performed exercise at 06:00 a.m at 75% of maximum heart rate during the study, while controls continued their normal life style. Changes in fasting S-IgA concentrations and cortisol serum levels were monitored at the beginning and end of exercise at [0900] a.m following every session. Analysis of data was performed, using t-student test for comparing means of pre and post test. Pearsons correlation was used to determine any relationship between S-IgA concentration with cortisol concentration. The level of significance was chosen at P

Sphincter preservation and pathologic response in rectal cancer undergoing neoadjuvant chemoradiation with and without oxaliplatin according to thymidilate synthase [TS] expression

Oxaliplatin [OX] significantly enhanced the antitumor activity of 5-FU in patients with advanced colorectal cancer and recently some phase II trials have evaluated the feasibility and efficacy of oxaliplatin in neoadjuvant setting for treatment of locally advanced rectal cancer. On the other hand various studies have demonstrated that the overexpression of thymidylate synthase [TS] can induce resistance to 5-FU in colorectal carcinoma. The aim of this study was to assess the value of TS expression as a predictive factor in the efficacy of neoadjuvant chemoradiation with and without oxaliplatin in rectal cancer. This study was performed in 61 patients [that ultimately 50 patients had including criteria] with locally advanced rectal adenocarcinoma that inferior margin of the tumor had to be located no farther than 6 cm from the anal verge. Preoperative radiotherapy was delivered to the pelvis with CO 60 to 50/4 Gy. All patients received simultaneous chemotherapy: 5-fluorouracil [5-FU], 300 mg/square meter i.v. 24 h infusion during radiotherapy on days 1-5 every week. Thirty patients received oxaliplatin 50-60 mg /square meter weekly during radiotherapy.TS expression was assessed by immunohistochemical staining technique in pretreatment specimen, and the patients were categorized into TS [+] and TS [-] groups. A total of 23 of 50 tumors showed TS positive status at biopsy [46%] . Overall 36 patients [72%] achieved pathologic response [40% complete and 32% partial] that was significantly better in the TS [-] group than in the TS [+] group [85.1 vs 56.5%, p=0.024] and in the OX [+] group than in the OX [-] group [86.6 vs 50%, p=0.005]. Among TS [-] patients there was no difference in pathologic response [88.2 vs 80%, p=0.561] or sphincter preservation [76.4 vs 80%, p= 0.831] as a result of whether oxaliplatin therapy was carried out or not. But among the TS [+] patients there was a significant gain in pathologic response [84.6 vs 20 %, p=0.002] and sphincter preservation [84.6 vs 40 %, p= 0.026] in favor of oxaliplatin group. Our study indicate that oxaliplatin can improves poor outcome of TS positive rectal cancer and TS expression may be used for selecting patients for oxaliplatin containing neoadjuvant chemoradiation protocols that can have major role in the tumor down staging and preservation of sphincter and ultimately better quality of life

[Frequency of mental disturbances in hemodialysis patients referred to hemodialysis ward of Khatam- Al- Anbia hospital in Zahedan]

Introduction: Hemodialysis as a treatment in chronic renal failure is a stressful process and has several psycho-cognitive and social complications. The latter can cause mental disorders in such patients

Objective: As a result of high prevalence of psychosis, this investigation was done to determine mental health status in hemodialysis patients and then compare it with normal population group

Materials and Methods: This cross sectional research was carried out on [40 dialysis patients in Khatam hospital of Zahedan and 40 healthy persons who were matched in variables such as age, sex, marital status and education in 2002. In this study, the mental health status of experiment and control group were assessed and compared using the standard questionnaire of general health from consisting of 28 questions by descriptive and analytical statistics

Results: Finding showed that dialysis patients [mean =11/65] have lower mental health state than control or healthy group [mean = 6/20]. The result of T test shows a significant relation between these two group [p<0/001]. Also there are statistical significant relation between mental health status of dialysis patients and dialysis times in a week [p<0/009] and sex [p<0/03]

Conclusion: Considering lower mental health status of dialysis patients in this investigation, It is recommended that the psychological team apply therapeutic interventions by assessing them before and during dialysis period which can be effective in patient adjustment, coping and health promotion