Comparative efficacy of filtered blue light [emitted from sunlight] and topical erythromycin solution in acne treatment: a randomized controlled clinical trial

Acne vulgaris is one of the commonest skin conditions .The visible light has attracted attention as a new and safe therapeutic option, as some studies show more than 80% response to 420 nm phototherapy with a significant reduction in inflammatory acne lesions after only eight treatments. We evaluated the use of blue light and topical erythromycin in 32 acne patients. The right-sided lesions were treated with erythromycin solution twice daily and the left ones were treated with irradiation of sunlight by a filter for 15 minutes once daily for 8 weeks and in another treatment group, the lesions in sides of the face were treated on reverse manner. The difference between the treatment and control sides was not significant at week 4, and 8 [p>.05]. After 12 weeks of starting the program, a mean improvement of 20% in lesion counts was achieved by the blue light phototherapy. In our study, a mean improvement of 46% in acne score was achieved with the blue light compared to 58% with topical erythromycin [p>0.05]. We found that visible light phototherapy improved partially acne lesions and may be an appealing noninvasive alternative for the treatment of acne

Study of factors related to accidents occuring during the construction phase of oil, gas and petrochemical projects

Construction phase in industries is a dynamic process that is naturally and intrinsically dangerous and as it becomes more complicated, the accidents rate also increases. One should note that without considering a model, one could not obtain useful and reliable information and method to prevent accidents. Therefore, to achieve useful methods for preventing accidents, it is desirable to consider a model. The general goal of this study was presentation of a model. A model is the reflection of a fact. In other words, it should be said that the model represents a system or process whose behavior can be predicted. Models are therefore used for understanding the behavior of actual terminals and show a theory in the way that covers important variables for describing phenomena and instead, ignore factors of low importance in the expression of those phenomena. This study was a research article conducted in 2004-2005 in the Assaluyeh region. Data was gathered from accident reports present in security and health records of the projects and also statistics present at the treatment centers. In this study, an analytical model [multi-regression] was presented to describe the impact of effective and deep factors on the possibility of an increase in accidents leading to death, through measurement of the effects of independent variables on the dependent variables. For this purpose, the structure of 50 accidents that led to death were studied along with another 2700 accidents, and after studying the accident reports and related documents, observing operations and equipment, counseling with accident observers and an expert team of managers, supervisors and engineers, and simulation of some accidents, unsafe conditions and functions, mismanagement and use of worn out and defective tools, equipment, devices and machinery were considered as the four independent variables and the job accidents leading to death were considered as dependent variables. The relationship between independent and dependent variables, evaluation of regression coefficients and the test of different models were based on multi-regression analytical model and analyzed using Eviews software program. The final findings of this study, while specifying the possibility of occurrence of accidents leading to death with the existence of any of the independent variables showed that among the independent variables, unsafe conditions and mismanagement have relatively more important roles to play in the occurrence of accidents leading to death such that in conclusion, these factors have been defined as root causes in the model. Since the adjusted coefficient determined for the model in this research was 0.99; that is, the specified model could describe 99 percent of changes related to the number of job accidents leading to death and it is only for one percent of other accidents that there was no justified answer. In another words, those causes were not seen in the model. Therefore, it could be concluded that this research as compared to similar researches gained more useful results. Thus, by omitting or lowering unsafe conditions and mismanagement factors, accidents resulting in deaths can be reduced

[Therapeutic effects of paromomycin sulfate in combination with grntamicine sulfate films on cutaneous leishmaniosis in Balb/c mice]

Leishmaniosis is a complex disease, with a wide spectrum of clinical manifestation affects over 12 million people globally. Cutaneous leishmaniosis is still an important public health problem in many parts of the world, especially the Middle East. In spite of various forms of local treatment none is generally suitable for all forms of the disease in all. In this reseal-cli, therapeutic effects of paromomycin sulfate in combination with gentamicine sulfate films on cutaneous leishmaniosis in Balb/c mice has been studied. According to data and experiments available in Iran and some endemic countries about treatment of the disease by paromomycin, a new physical form of the drug was designed [drug film] and parasiticidal effects were evaluated in mice model. The base of the fi111is, ethyl cellulose and HPMC [hydroxy propyl Methyl Cellulose] contained paromomyein 15% and gentamicine 0.5%. In this regard female Balb/c mice were infected with 2X l0-6 L. major promastigotes [MRHO/IR/75/ER]. The mice were divided in three groups, of ten mice each. The placebo and test groups were received prepared placebo and drug films respectively. The remaining group, control received no treatment. The results indicated that utilization of this physical form of the drug in a mentioned period of time caused significant cure effects in the test group, so that 80% of Balb/c mice were cured at the end of the treatment period and there was no sign of cure in placebo and control groups. In general and because of good characters of the drug films and related results in animals, it is possible to use the new form of the drug in a human trial

Carcinoma of the bladder metastasizing to the skin

This article attempts to describe a rare case of bladder carcinoma with skin metastasis. This case is interesting, particularly because it is related to the bladder. From a statistical point of view, metastatic carcinoma of the bladder is very rare. In this paper the clinical and histologic findings of a rare cutaneous metastasis from carcinoma of the bladder will be discussed

case of maffucci's syndrome with neurological complications

A case of Maffucci's syndrome with cutaneous, osseous and neurological complications is reported. The patient was normal at birth and developed multiple cutaneous hemangiomas and osteochondromas during childhood. He also developed multiple neurological deficits, including cranial nerve palsies due to intracranial calcification and osteochondromas