Serum pepsinogen in ulcer and non ulcer lesions

This study comprised 60 patients with ulcer and non ulcer lesions and 20 persons as a control group, with age ranging from 16-66 years. Three biopsies were taken from stomach, antrum and duodenum for pathological studies and radio- immunoassay detection of serum pepsinogens level. The results of this study showed increased level of serum PGI and high PGI/PGII ratio in cases with duodenal ulcers and duodenitis than those of control group, gastric ulcer patients and patients with gastritis. Also we found that elevated serum level of PGII with decreased PGI/PGII ratio in cases of gastric ulcer and patients with gastritis than those of control group, duodenal ulcer patients, patients with non ulcer lesions as patients with duodenitis and gastro duodenitis. Radio immunoassay of serum pepsinogens I and II are considered as a good markers for detection of early gastro duodenal lesions and they are markedly changed in established cases with duodenal or gastric ulcers

Ultrasonographyic and histopathological study of the gallbladder in bilharzial periportal fibrosis

Ultrasonographic scanning of 100 patients with bilharzial periportal fibrosis was done and showed that the incidence of gallstone was 7%. These patients showed also a statistically significant increase in gallbladder wall thickness in comparison to control patients Mean, 6.41mms and 1.9mms respectively. Cholecystomy and pathological examination of the removed speciemen was performed in 20 bilharzial patients.Chronic inflammation was found in 90% and bilharzial granuloma in 10%.From this study, its shown that the high incidence of gallstone in patients with bilharzial periportal fibrsis could be explained in addition to the role of the liver by gallbladder disease proved ultrasonographically and pathologically