ABSTRACT
Tuberculosis is a worldwide infectious disease and BCG is the only available vaccine against this infection. This vaccine is injected intradermally [0.05 cc] in the first day of life. The complications of BCG vaccine are: local ulceration, regional lymphadenopathy, lymphadenitis, abscess formation and fistulization, osteitis or osteomyelitis, systemic reactions, hypersensitivity and granulomatosis reactions. There has been hardly any study on complications of BCG in Iran; therefore we decided to evaluate the rate of the most important complications of this vaccine [lymphadenopathy, lymphadenitis, abscess formation, and fistulization] in Semnan. All 557 babies born at Amir-al-Momenin and Shafa Hospitals during a 6-month period between March and September 2003 were assessed. In our study, BCG vaccination was performed for all these neonates at the hospitals. Then, the babies were examined monthly by a physician and the questionnaires were filled in. The rate of lymphadenopathy, lymphadenitis and fistulization of the abscess after BCG vaccination were 2.2%, 0.54%, and 0.18% respectively. There was no significant difference between the incidences of the complications in the two hospitals. Moreover, no significant difference was observed between the sex of the babies and the occurrence of the complications. The survey illustrated a higher rate of lymphadenopathy and lymphadenitis after BCG vaccination compared with the other countries' studies
ABSTRACT
Silymarin is the seed extract of silybum marianum herbal medicine widely used for liver and bilary abnormality in China and several European country. It protect liver from several toxicity including acetaminophen, alcohol and amanita mashrom poisoning. Silymarin is composed of several flavonoids with antioxidative, anti-inflammatory and increasing cellular glutathion level properties. Although several experimental and clinical investigation indicating its efficacy against liver and prostate cancer, cisplatin induced kidney toxicity, and type II diabetes, but further clinical study need for its clinical use. However no adverse effect is reported by its chronic use or its administration to children, or pregnancy and lactation women