[ rare case of lissencephaly and literature review]

Lissencephaly, which literally means [smooth brain], is a brain formation disorder characterized by the lack of normal convolutions [folds] in the brain, and an abnormal small head size [microcephaly]. It is caused by defective neuronal migration, the process in which nerve cells move from their place of origin to their permanent Location. The incidence is unknown. Manifestations occur in neonate or in childhood. There are multiple anomalies in eyes, heart, kidney and gastrointestinal system. In this study, we introduce a female neonate with poor feeding and microcephaly. The aim is to enhance the importance of diagnosis and to distinguish this disease from preventable diseases with similar manifestations