Mercury[II] cystine complex as antineoplastic agent

Antineoplastic activity of mercury[II] cystine complex was studied against ehrlich ascites carcinoma [EAC] cells in Swiss Albino mice. Cell growth inhibition, increase of life span, haematological parameters, alkaline phosphatase activity of tumour bearing mice inoculated with EAC cells were studied with the test compound. It was found that this compound significantly inhibited the tumour cell growth, enhanced life span of the tumour bearing mice at dose 6 mg/kg i.p. Such treatment also restored the altered haematological parameters and serum alkaline phosphatase activity very closely towards normal. The compound can be considered as a potent antineoplastic agent

Antineoplastic activity of nickel [II] cystine complex against ehrlich ascites carcinoma in swiss albino mice

Ni[II]-cystine complex was synthesized by treating saturated aqueous solutions of Ni [II] acetate and L[-] cystine [in 1: 1 molar ratio]. The complex was used to study its antineoplastic activity against EAC cells in Swiss Albino mice. It was found that the Ni [II] complex restored the depleted haematological and biochemical parameters of the EAC bearing mice towards normal values and enhanced the longevity of such mice significantly. The test compound on the other hand showed negligible host toxicity. The results obtained were compared with those obtained with a standard anticancer drug bleomycin

Social aspects of patients with carcinoma breast presented to Sir Ganga Ram hospital Lahore

This study was carried out in Sir Ganga Ram Hospital from January 2001 to December 2003. 525 patients with carcinoma breast were selected and a detailed demographic record was maintained. It was seen that the largest no. of cases were between 30-39 years i.e., 37.33% Socioeconomic status showed that 47.24% belong to lower group 80.38% were house wives Marital status showed 97.14% were married 66.67% patients belong to rural areas. Age at the time of first pregnancy was between 22-27 years i.e., 75% of cases. Average number of children was 5 seen in 52.78% cases. Lactation status showed 41.67% had breast fed their children for 18 months. Family history was positive in 2.7% patients. Average size of the lump was 6-10cm i.e 55.6%. It was T3 tumor in 47.22% of cases

Antitumour and antiinflammatory activities of hydroxamic acids and hydroxyurea

Antitumour activity has been evaluated using aceto [AHA], benzo [BHA], salicyl [SHA] cloroaceto [CHA], hydroxamic acids and hydroxyurea [HU] against Ehrlich ascites carcinoma [EAC] cells in Swiss albino mice. Anti-inflammatory activity of these compounds has also been studied in Sprague Dawley rats. Among these compounds only. CHA shows both antitumour and anti-inflammatory activities significantly. Although HU possesses highly effective antitumour activity, it does not show anti-inflammatory activity at all. Other compounds show differential antitumour and anti-inflammatory activities