Large giant cell tumor of the temporal bone presenting as mild conductive hearing loss

Giant cell tumor of bone or osteoclastoma is a relatively rare primary neoplasm of temporal bone. It usually involves the epiphyseal region of long bones. Primary involvement of bones of the skull appears to be uncommon. we report a case of giant cell tumor of temporal bone arising in a 33 years old man. The presenting symptom is only mild conductive hearing loss. A computed tomography [CT] scan showed a large well circumscribed mass within the right temporal bone, the posterior cranial fossa and the infratemporal fossa. Biopsy and subsequent resection showed a giant cell tumor of bone. Temporal bone tumor may be presented with symptoms such as mild hearing loss or aural fullness. So we always must be attention rare reasons of common symptoms

Detection of HHV-8 and HTLV-1 sequences in Kaposi's sarcoma

Kaposi's Sarcoma[KS] is a common malignant tumor in immuno compromisedindividuals and in organ transplant recipients due to immunosuppressive drugs. The correlationof lymphotropic viruses such as HHV-8 and HTLV-1 to KS is currently being studied. Theseviruses may be the risk factors or the primary cause of KS. The presence of HHV-8 and HTLV-1 genome was determined in archived skin biopsies diagnosed as KS. In this study we selected 35 paraffin embedded skin biopsies with KSdiagnosis. These diagnoses were reconfirmed by careful microscopic examination. Five micronthick sections of the blocks were prepared; and after deparaffinization, their DNA was extracted.Using LTR, tax and pol specific primers and ORF-26 and ORFK9-1 specific primers the HTLV-1 and the HHV-8 genomes were amplified, respectively. Our results indicate that none of the KS tissues were infected with HTLV-1, howeverwe detected the presence of HHV-8 genome in all of the specimens. According to these findings, it seems that HTLV-1 infection does not affect theprocess of HHV-8 activation

Value and accuracy of fine needle aspiration cytolbgy [FNAC] in thediagnosis of breast masses

Breast cancer is the most common malignancy of the women and causes death inmany patients every year. About 70% of breast surgeries and biopsy taking are not necessarybecause they yield benign diagnosis. For diagnosing breast masses accurately and speciallydifferentiating benign from malignant tumors without surgery, Triple Test has been introduced.This project tried to evaluate the diagnostic value and accuracy of fine needle aspiration cytologyof the breast as the most significant element of this test. During a 3 years period, 120 females with the chief complaint of abreast mass being admitted in Mashhad Imam Reza Hospital were subjected to all components ofthe triple test followed by confirmatory open biopsy. In 100 patients all paraclinical procedureswere obtained and the results were available. FNA cytologic results were classified in three groups as benign, malignant andsuspicious for malignancy. Fifty-five patients had benign and 40 had malignant cytology whichwere confirmed by routine histopathology. From 5 patients with suspicious cytology, 2 yieldedmalignancy and 3 benignancy by tissue confirmation. FNA cytology of the breast is a well tolerated, simple, safe, accurate, cost effective,noninvasive, less complicated procedure and operable in office practice for diagnosing breastlesions, with an accuracy of about 100%, specially when it is employed in association withphysical exam and mammography in the triple test.Based on these results we strongly recommend application of this method as an ideal procedurefor breast diagnosis and elimination of open biopsy in our country, which certainly will result inexpenses reduction