ABSTRACT
The use of antibiotics in conjunction with scaling and root planning is indicated in several cases of periodontitis. Azitbromycin is effective against gram negative microorganisms and has a long half life. The aim of this study was to evaluate the effectiveness of Azithromycin on clinical parameters in patients with chronic periodontitis. This randomized double-blind placebo-controlled clinical trial was conducted by recruiting 40 patients with chronic periodontitis referring to the Periodontics Department of Tehran University Dental School. The Papilla Bleeding index [PBI], Probing Depth [PD], and Clinical Attachment Level [CAL] were measured. The clinical examination was folloed by scaling and root planning [SRP]. Patients were assigned randomly to test [Azithromycin, 500 mg once daily for 3 days] and control [placebo, once daily for 3 days] groups one month after SRP. All parameters were measured again 2 and 4 months after baseline evaluation. Before administration of antibiotics [one month after baseline] the levels of clinical parameters [PBI, PD, and CAL] were not statistically different between the test and control groups. All clinical parameters [PBI, PD, and CAL] were significantly improved in both test and control groups one month after baseline [P<0.05]. In addition, all parameters were significantly lower in test group when compared with control group at 2 and 4 months [P<0.05]. Within the limits of this study, oral administration of Azithromycin in conjunction with scaling and root planning was useful in the treatment of moderate to severe chronic periodontitis
Subject(s)
Humans , Azithromycin , Treatment Outcome , Double-Blind Method , Randomized Controlled Trials as TopicABSTRACT
The aim of this study was to evaluate the clinical efficacy of an herbal medicine, Piascledine, on the treatment of chronic periodontitis. Twenty-four patients with chronic periodontitis participated in this interventional case control investigation. After initial screening the subjects were divided into case and control groups. Clinical measurements including plaque index [PI], bleeding on probing [BOP], probing pocket depth [PPD], bone level [BL] and clinical attachment level [CAL] were recorded for both groups, before and one month after scaling and root planing [SRP]. The case group received 300 mg Piascledine capsules once a day for three months and the control group was only treated with SRP. The measurements were repeated in both groups at the 3 and 6 month recall visits. Improvements were observed in all clinical parameters in both groups during the study period. PI as a covariate factor showed no significant difference between the two groups [P>0.05]. On the other hand CAL, BOP, PPD and BL showed reduction in all patients, but no significant difference was found between the two groups. According to the results obtained in the present study, Piascledine does not seem to have a favorable effect in the treatment of chronic periodontitis
Subject(s)
Humans , Male , Female , Phytosterols , Plant Extracts , Vitamin E , Drug Combinations , Chronic Disease , Persea , Glycine max , Case-Control StudiesABSTRACT
Several risk factors directly affect the development of periodontal diseases. Also some systemic diseases act indirectly as predisposing and aggrevating factors. Osteoporosis is one of these factors and one of its main causes is lack of physical activity in postmenopause period. The incidence of osteoporosis is increasing in our country. The goal of this study was to evaluate the periodontal condition of women with osteoporosis and osteopenia referred to bone densitometric division of Loghman hospital in 2003 and compare to control group. In this case control study based on BMD [Bone Mineral Density] measurement of back and thigh using DEXA method, 60 patients referred to bone densitometric division of Loghman hospital, were randomly selected. Cases were divided into three groups, 20 with osteoporosis, 20 with osteopenia and 20 normal cases. Periodontal indices consisting of plaque index [PI], tooth loss [TL], gingival recession [GR], probing pocket depth [PPD] and papilla bleeding index [PBI] were evaluated by clinical and radiographic examination. Data were analyzed by Kruskall Wallis and Dunn tests with p<0.05 as the limit of significance. PBI, PI and TL were significantly higher in osteoporotic group than osteopenic and normal group. PPD was not different in the three groups. Due to the low prevalence of recession in our study, this parameter was not included in the statistical analysis. It seems that osteoporosis does not increase the incidence of periodontal diseases because it affects bone quality rather than quantity. In osteoporosis calcium deficiency and increasing age lead to decreased physical activity and ultimately affect the patient's oral hygiene performance. Thus, periodontal manifestations are presented as gingival bleeding and gingivitis
ABSTRACT
Reconstruction methods are an essential prerequisite for functional rehabilitation of the stomatognathic system. Platelet-rich plasma [PRP] offers a new and potentially useful adjunct to bone substitute materials [e.g. Xenografts] in oral and maxillofacial bone and implant reconstructive surgery. An animal study was carried out to investigate the influence of PRP on the regeneratio of non-critical sized bony defects, treated with Deproteinized Bovine Bone Mineral [DBBM]. Eight New Zealand white rabbits were included in this randomized, pilot study. Three equal cranial bone defects [3×6 mm] were created and immediately grafted with DBBM and PRP+DBBM; one of them was left unfilled to serve as a control. The defects were evaluated using histologic and histomorphometric analysis at 2, 4, 8 and 12 weeks. The histomorphometric findings showed a significant increase in bone area and trabecular maturity in experimental defects as compared to the control at 4, 8 and 12 week intervals. A significant increase in bone formation was seen with the addition of PRP to DBBM at 2, 4 and 8 week intervals. At 12 weeks, the level of bone formation was similar between the two groups. There was also a significant increase in the rate of biodegradation of the DBBM particles with the addition of PRP at 2, 4, 8 and 12 weeks. No foreign body reaction and severe inflammation was seen in any of specimens. Within the limitations of this pilot study, it was concluded that the addition of PRP to Xenogenic bone substitute material in non-critical-sized defects of the rabbit cranium showed a histomorphometric increase in bone formation [until the 8th week of healing] and a greater amount of biomaterial degradation throughout the study period
ABSTRACT
AIDS is a contagious disease that due to the absence of a definitive treatment and high prevalence, sterilization of contaminated instruments must be taken in to consideration. Dentist, upon the examination of the oral manifestations of AIDS, can play a critical role in diagnosis and prevention of further risks. The aim of the present study was to evaluate the knowledge, attitude and performance of dentists of Golestan Province, correspondent with treatment services insurance about the infection control and prophylaxis of AIDS. To do this study. 104 general dentists were thoroughly studied by a check list consisted of 32 questions arranged in three parts on knowledge, attitude and performance. The first part was completed by the dentists and others were completed by a student upon the observation of their offices. The knowledge level of the major of dentists was good [52%], their attitude was excellent [64.4%] and the performance of 66.3% was good. Most of the dentists employed disposable instruments. [Suction and glass 100%, apron 70.2% and needle 99%]. They observed individual shielding covers [Single-use gloves 92.3%, protective glasses 82.7% and clinic dress 96.2%] Autoclave as the only sterlizator instrument was observed in half of the clinics [50%], however, autoclave and oven were in 42.3% of the clinics. The most commonly used antiseptic was microten [92.3%]. It was concluded that the knowledge and attitude of dentists were at a high level although their performance was weak. Thus, they should be provided with facilities on dental equipment and periodic education
ABSTRACT
Aim and Background: the application of mouthwashers along with periodontal treatments, particularly of herbal origin, is of high importance. In this research, the effects of chlorhexidine [CHX] and persica, at the first stage of the periodontal treatment, were compared and the indices of pocket probing depth [PPD], papillae bleesing [PBI] and clinical attachment level [CAL] were investigated
Methods and Materials: this cross - sectional study was conducted on 46 patients referred to the periodontics department of dental Faculty, Tehran University of Medical Sciences [2000-20001].The patients were divided into test and control groups and the indices of PPD, PBI and CAL were recorded. After the first stage of the periodontal treatment including scaling and root planning, Polling rooth - brusing method and the use of dental floss were taught to the patients. For test group. persica and for the controls chlorhexidine 0.2%, twice daily, were prescribed. After one month, all these indices were recorded. To analyze the data, t-test and variance analysis were used
Results: the average PPD reduction in test and control groups were 0.61mm and 0.96mm, respectively. The average PBI reduction were 1.20 and 1.17 for test and control groups, respectively. NO significant difference was found in CAL between both groups. Chlorhexidine staining was observed among most of the control group patients but no side effect was found among test group
Conclusion: finally, it is concluded that persica mouth wash at the first stage of the periodontal treatment in gingivitis and periodontitis, can be considered useful