[Formulating and assessing evaluation indictors of administrative reform: a case study]

Introduction: The administrative reform is one of the means to achieve economic social and cultural policy development. Given the necessity of administrative reform monitoring, this study aimed to identify and measure the indicators of administrative reform in the medical school of Tehran University of Medical Sciences

Methods: A mixed sequential qualitative-quantitative approach was employed. The indicators of evaluation were identified through document analysis. In the first phase, 8 semi-structured interviews and the views of 5 experts were collected. Then, we used a researcher- developed checklist to evaluate the current status of the selected school. The checklist was completed through on-site visiting, observation, interview and document review which were then analyzed manually

Results: A set of 150 indicators of administrative reform evaluation, categorized in 10 domains and 36 areas was identified. The total score of evaluation was 28%. The employment equity and payment system domain showed the highest score [55%] and the organizing of human resources domain lowest score

Conclusion: Given the relatively poor results of the administrative reform and the continuity of the reform in Iran development plans, we recommend accelerating the efforts of defining and implementing the administrative reform. Our developed checklist can be used by policy makers and managers

Establishment of autochthonous and standard cell line derived xenograft models of glioblastoma multiform in Iran

GBM is the most common and malignant astrocity tumor and it is persistent to common treatment so, these patients have a very low survival. Several researchers around the world, including Iran, have been investigated GBM-cell line in vitro. However in vivo studies have not been fulfilled. As standard cell line [U-87MG] derived from human GBM and total GBM tumor derived from 3 patients were heterotypic ally injected into 4-6 weeks old athymic nude mice. Pathologic investigation by H and E, GFAP and Ki-67 were examined 2 months post implantation. GBM characteristics appeared in H and E and GFAP and the rate of proliferation was 6% and in direct xenograft tumor was 9% which was consistent with the pathologic result of patient. GBM Xengraft is the most suitable model for in vivo investigation and researcher can evaluate new treatments for this tumor. On the other hands, Pharmacogenomics differences in treatment response could be indicated among Iranians