ABSTRACT
To compare the efficacy of topical nasal application of Azelastine HCL with Beclomethasone in treating perennial allergic rhinitis. It was a quasi-experimental interventional study conducted on 60 patients of Allergic Rhinitis, presenting to ENT Department Combined Military hospital Rawalpindi from 1[st] January 2008 to 30 June 2008. Patients fulfilling the criteria were divided into two groups of 30 patients each. Group I was given Azelastine nasal spray, while group II was given Beclomethasone nasal spray for topical application. Out of sixty patients 37 were males and 23 were females. Mean age for group I was 28.97 years with Standard Deviation of 6.13. In group II, mean age was 28.3 years with Standard Deviation of 5.62. The symptoms of Perennial Allergic Rhinitis were better controlled in patients treated with topical application of Beclomethasone as compare to Azelastine. Beclomethasone is more effective than Azelastine for the control of the symptoms of Perennial Allergic Rhinitis
Subject(s)
Humans , Male , Female , Beclomethasone , Phthalazines , Anti-Allergic AgentsABSTRACT
Ovariectomy of the mature female rat results in a fall in the plasma vasopressin concentration, although the ovarian content of the hormone is low. To investigate this further, functional ovariectomy was done in the rats by administration of an anti-oestrogen acting drug [Tamoxifen]. Studies performed on female rats indicated significant reductions in uterine weight and plasma vasopressin levels. The uterine weights decreased from 206.9 mg /100 gm body weight in control group to 142.2 mg /100 gm body weight in experimental group. Plasma vasopressin levels decreased from 1.15 microunits / ml in the control group to 0.38 microunits /ml in the experimental group. The study confirms that like surgically ovariectomized rats, functional ovariectomy also causes decreases in uterine weights and plasma vasopressin levels