ABSTRACT
TSH-secreting adenomas are rare; they represent less than 2 or 3% of all pituitary adenomas. We report a case of TSH-secreting adenoma in a 52 year old man revealed by cardiac arrythmia. The diagnosis was made in presence of hyperthyroidism with a TSH in the upper limit of normal value, with an increase in the alpha sub-unit and with the presence on the MRI of a pituitary macroadenoma. The patient was treated with somatostatin analogues before transphenoidal surgery. TSH-secreting adenomas are classically revealed by hyperthyroidisni with inappropriate secretion of TSH and a pituitary adenoma. Transphenoidal surgery is the recommended treatment but the results are not always satisfactory because most adenomas are invasive macroadenomas. Somatostatin analogues improve management and prognosis of these adenomas
Subject(s)
Humans , Male , Adenoma , Thyrotropin , Disease Management , Review Literature as Topic , Arrhythmias, Cardiac , Hyperthyroidism , Magnetic Resonance Imaging , Somatostatin/analogs & derivatives , Pituitary Neoplasms/surgeryABSTRACT
The incidence of otospongiosis is high, in the delegation of NabeuI, Dar Chaabaneand Hammamet These zones seem to be the homes of origin of this disease.The expression of otospongiosis is variable according to age and sex. The maximal period of risk is between 26 and 35 years in woman, and begins until 35 years in men. The cumlated incidence is 2,9% in women, and 1,3% in man. This female predominance was tied up on endocrinis factors, and had not been due to genetic transmission then, the analysis of familial data suggested the existance of genetic constituant in the etiology