ABSTRACT
Momordica Charantia [MC] belongs to the cucurbitaceae family. MC is A plan that is widely used in traditional medicine as an antidiabetie agent.The aim of the present study was to evaluate the effect of the raw fruit of MC on some blood biochemical parameters in rats. Three groups of rats received a diet containing 1%, 2% and on MC [control group] respectively for a duration of two months. Blood samples were collected in the begining and at the end of the study. The sera were separated and used for determining of biochemical parameters including fasting blood suger [FBS]. glycated hemoglobin [HbAlc], cholesterol [cho], high density lipoproteins [HDL], low density lipoproteins [LDL], triglycerides [TG], urea [U] and creatininc [C]. The diet containing 1% and 2% MC decreased FBS significantly [p<0.002], and HbAlc [p<0.004] as compared to the control group. The 2% MC diet decreased Cho [p<0.001] and LDI [p<0.001] as compared to the control group. There was no significant change in the other factors. On the basis of the results obtained, it may be concluded that MC can effectively normalize glucose and lipid in patients. For better conclusion experimental human studies are recommended