ABSTRACT
Background: Although hydro-alcoholic extracts of Anethum graveolens L. had Anticonvulsants effect on PTZ-induced kindling seizure behavior, but on the amygdala kindling in rats induced seizure has not been investigated
Objective: In this study, we evaluated the chronic effects of hydro-alcoholic extracts of Anethum graveolens L. on seizures using electrical amygdala kindling model
Methods: Rats were divided into six groups. They were kindled by stimulating the amygdala by consecutive daily. Then, treated by hydro-alcoholic extracts of Anethum graveolens L. [i.p. 100, 200 and 400 mg/kg] and Afterdischarge Duration [ADD], Stage 4 latency [S4L] and Stage 5 duration [S5D] were recorded
Results: Hydro-alcoholic extracts of Anethum graveolens L. [200 and 400 mg/kg] significantly increased stage 4 latency compare to the control group [P <0.05]. Hydro-alcoholic extracts of Anethum graveolens L. [400 mg/kg] injection stage 5 duration caused by amygdala electrical kindling. Hydro-alcoholic extracts of Anethum graveolens L. [100, 200 and 400 mg/kg] injection significantly reduced ADD induced by amygdala kindling
Conclusion: The data showed that injection of hydro-alcoholic extracts of Anethum graveolens L. has anti-epileptic effect and increases the time required for amygdala kindling and may have anticonvulsant effects