ABSTRACT
Background: hyperbilirubinemia is a common problem in neonates but sever hyperbilirubinemia will cause kernicterus. The aim of this study is to evaluate the efficacy of oral clofibrate in treatment of indirect hyperbilirubinemia in non hemolytic jaundiced full term neonates
Materials and Methods: in one clinical trial study were evaluated 60 healthy full term neonates with non hemolytic jaundice . 30 neonates [control group] received only phototraphy while the other 30 neonates treated with a single oral does of clofibrate [100mg/kg] with phototraphy. Two group were compared by the mean plasma total and indirect bilirubin after treatment and duration of hospitalization and need for exchange transfusion
Results: total and indirect bilirubin levels after treatment showed that decreasing amount of total and indirect bilirubin within time in clofibrate - treated group significantly is more than control group. also the average duration of hospitalization and need for phototraphy on clofibrate - treated group is lower than control group. In the studied neonates with a single dose of clofibrate no side effects were observed during hospitalization and after discharge
Conclusion: up to now many pharmacological agent have been used for prevention or treatment of neonatal jaundice. Drugs such as Phenobarbital, Activated charcol and plain agar and metalloporphyrins have been used for this purpose but None of this drugs has been accepted completely by efficacy and safety and not available for routine use. Clofibrate due to it's ideal efficacy in decreasing bilirubin and duration of hospitalization and oral easy use and availability of this drug is considered tobe suitable treatment way for neonatal nonhemolytic jaundice