Adenoids and serous otitis media in Karachi

Adenoiditis and Serous otitis Media is a rare problem in current practice in Karachi. This is in complete contrast to the huge problem this disease has created for developed nations

Pharmacological screening of medicinal plants [II]

This work deals with the effects of the alcoholic extracts if 15 plants [collected from the northern region of Pakistan] on isolated guinea-pig ileum preparation. Dried powdered plant material was extracted with alcohol. The extract obtained after the removal of the alcohol was titrated! with pet-ether [40-60] and then charcoaled, filtered and dried under vacuum. The isolated guinea-pig ileum preparation was set up in an organ bath of 10 ml capacity containing exygenated Tyrode solution. A 10 mg/ml solution/suspension of the extract [in distilled water] was added to the bath in 100-800 micro g/ml concentrations. Those extracts which did not produce a spasmogenic effect, were tested for antispasmogenic action against acetylcholine. The extract of Cleome brachycarpa, Fagonia cretica and linum usitatissimum produced spasmogenic effect. The extracts of Asperugo procumbens, Capparis decidua, Cichorium intybus, Cnicus arvensis, Euphorbia hirta, Equisetum arvense, Eugenia jambolana, Forsskalea tenacissima, Onosma echiodes, Peganum harmala, Prospopis glandulosa and Ranunnculus muricatus antagonized the spasmogenic effect of acetylcholine

Effect of adrenaline and nor adrenaline on insolated ratureter preparations

The effect of adrenaline and non-adrenaline on the spontaneously contracting and quiescent isolated proximal and central pieces of ureters obtained from female [virgin] albino rats of the Sprague Dawley strain were studied. Adrenaline and nor-adrenaline produced a stimulant effect on the rate and amplitude of the proximal pieces of spontaneously contracting preparations. Both these drugs induced persistaltic activity in similar quiescent preparations. Adrenaline also produced a stimulant effect on the spontaneously contracting preparations of the central portions of the ureters. In view of these findings it is suggested that as far as the responses to adrenaline and nor-adrenaline are concerned, the proximal and the central portions of the isolated rat ureter preparations behave as if they possess a preponderance of alpha [excitatory] adrenergic receptors