ABSTRACT
To verify the myofibroblastic origin of spindle cells by immunohistochemistry in idiopathic inflammatory pseudotumor [IPT] of the orbit. We reviewed a series of 32 orbital IPTs for expression smooth muscle actin [SMA], Vimentin, Desmin and anaplastic lymphokinase [ALK]. The study was performed on histologic samples of 33 patients with a diagnosis of orbital IPT. The lesions expressed SMA in 51.7%, Vimentin in 72.0% and Desmin in 17.2%. All lesions were negative for ALK. Reactivity for SMA in spindle cells may indicate their myofibroblastic origin. The absence of ALK expression in all cases strongly suggests that these lesions, although histologically similar, are biologically distinct from their soft tissue counterparts. IPTs which are negative for ALK may be characterized by one or more chromosomal aberration involving regions other than 2p23
ABSTRACT
To determine the frequency of congenital nasolacrimal duct obstruction [CNLDO] in premature newborns and its correlation with gestational age [GA], sex, family history and chronological age. This study was performed on infants who were referred for retinopathy of prematurity from 2002 to 2003. Cases of CNLDO were visited again three and six months later. This study was conducted on 60 preterm infants [26 male, 34 female] with gestational age of 33.2 +/- 1.3 weeks [range 25-36] and age of 3.8 +/- 0.9 months [range 1.5-6] at first presentation, of which 13 had CNLDO [9 unilateral and 4 bilateral]. Overall, 17 out of 120 ducts [14.1%] were obstructed. There was no correlation between CNLDO and sex, family history or gestational age. Three months later 58.4% of the obstructions were cleared and at the 6 month visit, 25% of residual obstructions were cleared, such that the total remission rate at 6 months was 83.4%. In premature newborns with CNLDO, the rate of spontaneous clearing of the obstruction is greater than 80% during the first 6 months
ABSTRACT
Normal values for CT orbital measurements, which appear in reference books, may not be applicable to the Iranian population. The purpose of this study was to determine normal values in an Iranian population and compare them with published standards. Orbital CT scans from adults were studied from March 2003 to June 2005. The scans had been ordered for complaints unrelated to craniofacial and orbital abnormalities, and in all of them, the presence of any pathology of the bones, globe and orbit were excluded. Four hundred CT scans [134 females, 266 males, mean age 36.9 +/- 16.7 years] were studied. The normal interorbital distance at the posterior border of the frontal process of the maxilla measured from 1.8 to 3.5 cm [mean 2.30] in men and 1.5 to 3.2 cm [mean 2.17] in women [p<0.01]. At the level of orbital equator, the mean interorbital distance was 2.46 cm in women [range 1.7-3.2] and 2.65 cm in men [range 2-3.4] [p<0.01]. Compared with the corresponding values of interorbital standards, all these measurements were smaller. Normal values of orbital measurements are smaller and more varied in Iranian population and these values must be used when interpreting CT scans of the orbit
Subject(s)
Humans , Male , Female , Tomography, X-Ray Computed , Craniofacial AbnormalitiesABSTRACT
To assess the histopathological and immunohistochemical features of orbital spindle cell tumors. A descriptive, retrospective study was performed on 63 pathology reports on all types of orbital spindle cell tumors at the pathology department of Farabi hospital between 1995 and 2005. Immunohistochemistry studies for different markers, such as smooth muscle actin, Desmin, S100 protein, CD31, Factor VIII, CD 68 and CD34, were carried out in cases with indeterminate origin on routine histopathologic study to achieve a definitive diagnosis. Our study included 63 cases with average of 30 years including 62% female and 38% male subjects. The leading types of orbital spindle cell tumor in our study in order of frequency included: benign nerve sheath tumors [46.0], rhabdomyosarcoma [11.1%], hemangiopericytoma [7.9%], fibrous dysplasia [7.9%], ossifying fibroma [4.8%], fibrous histiocytoma [3.2%], and other types [19.1%]. From 29 cases with benign nerve sheath tumor, 16 cases [25.4%] were neurofibroma and 13 cases [20.6%] were schwannoma. The orbital tumors were benign in 74.7% and malignant in 25.3%. The most common type of orbital spindle cell tumor in this study was benign nerve sheath tumor. Immunohistochemical studies for different markers are required for definitive diagnosis of cases with indeterminate origin on routine histopathological study