ABSTRACT
Introduction: Chronic kidney disease (CKD) has been recognized as a leading public health problem worldwide. The global estimated prevalence of CKD is 13.4%. Kidney plays a critical role in regulating serum levels of Calcium, Magnesium and Phosphate. Calcium, phosphorus and magnesium homeostasis is altered in chronic kidney disease(CKD). Objective Objective: of the study is to establish the correlation of increase in serum creatinine levels with Calcium, Magnesium and Phosphate levels in patients. Design & Methods: This observational retrospective study included patients attending nephrology department in tertiary care centre for a period of two months. In total, 229 patients' data was accessed from the medical records. Patients were grouped in 5 groups based on serum Results: creatinine levels. Group I with serum creatinine levels of 0.5mg/dl to 0.8mg/dl, group II with serum creatinine levels of 0.8 to 1.1mg/dl, group III with serum creatinine levels of 1.1 to 3mg/dl, group IV with serum creatinine levels of 3 to 6mg/dl, group V with serum creatinine levels above 6mg/dl. Overall from group I to Group V , Serum Calcium showed negative and significant correlation, Serum phosphorus levels showed positive and significant correlation, Serum magnesium showed negative and insignificant correlation with serum creatinine. As Conclusions: serum creatinine increases, more patients show decline in serum calcium levels and serum magnesium levels and increase in serum inorganic phosphorus levels. Hypocalcemia, hypomagnesemia and hyperphosphatemia have been associated with increased risk of cardiovascular morbidity and mortality in cases of CKD. Hypomagnesemia has possible association with rapid decline in kidney function. Therefore, regular analysis of these parameters is important for predicting the prognosis of CKD and cardiovascular risk in cases of CKD.
ABSTRACT
The major disability among the various professionals worldwide is musculoskeletal disorders. They impose a burden to the community in both direct costs to health care and indirect costs through reduced work efficiency and productivity. In India, according to epidemiological studies, the community based prevalence of musculoskeletal disorders is about 20% and occupation specific prevalence is as high as 90%. Among the victims, the prevalence of musculoskeletal disorders among Dental surgeons is about 64%, out of which 80% had low back pain at some point of time in their life. Despite the burden, musculoskeletal disorders have not been considered in National health programmes. Bearing in mind musculoskeletal disorder as a public health burden, engaging Chiropractic- a complementary type of medicine in screening and as a part of primary prevention will be a great effort in reducing the future burden to the community.