ABSTRACT
Background: Chronic kidney diseaseis an increasing health problem worldwide Thus apart from the well-established risk factors for CKD such as diabetes and systemic hypertension, the possibility that environmental, demographic, and various other risk factors an influence in developing chronic kidney disease has been assessed in several studies. Hence, the present study aimed to study the clinical and laboratory profile of chronic kidney disease in non-diabetic and non-hypertensive patients Methods: The study was enrolled 100 patients diagnosed with chronic kidney disease without diabetes and systemic hypertension in the department of general medicine and department of nephrology in a tertiary care hospital, Pondicherry for 1 year. The baseline data such as socioeconomic status, history of self-consumption of natural medicine and NSAIDs, their occupations, location of their living place, and routine laboratory parameters were collected and analysed. Results: The socioeconomic status of the present study revealed that upper lower class was thepredominant status and the majority of the patients were housewives and farmers. 38% of the patients were exposed to insecticides that were associated with CKD (p=0.0327). 40% of the study population was victims of NSAID consumers (p=0.0236). 42% was consumed natural medication on their own for their illness 46 without any consultation (p=0.0324). The patients came from Cuddalore predominantly (22%). Conclusions: Insecticide exposure, self-consumption of NSAIDs, and natural medicine are the main causes that progress to CKD in the present study.
ABSTRACT
Background: Subclinical hypothyroidism (SH) is characterized by elevated levels of serum thyroid stimulating hormone in the presence of normal thyroxin levels. Subclinical hypothyroidism is often associated with elevated total cholesterol and other lipid profile parameters. This study was done to evaluate the lipid metabolism in subclinical hypothyroidism.Methods: This case control study was done to compare the lipid profile parameters between subclinical and overt hypothyroidism cases attending the outpatient facility of our tertiary care hospital of our medical college in Puducherry. Newly diagnosed cases of hypothyroidism were selected by convenient sampling. A total of 37 SH cases and 31 overt hypothyroidism cases were included. Blood samples were drawn to measure lipid profile. A 2D echocardiogram was done to evaluate cardiac function. Ultrasonogram was done to evaluate fatty liver.Results: The mean age of the participants in the subclinical hypothyroidism group was 34.2±12.2 years while in the clinical hypothyroidism group was 35.7±9.8 years. About 13.5% of the participants in subclinical hypothyroidism group and 12.9% of the participants in clinical hypothyroidism had fatty liver in ultrasound. A significant difference was observed in the mean values of total cholesterol, triglycerides and LDL levels between clinical and subclinical hypothyroidism.Conclusions: This study highlights the need for screening of subclinical hypothyroidism in order to prevent the incidences of cardiovascular complications and other diseases like metabolic syndrome.