ABSTRACT
Background:Changes in blood cell profile were common findings in malaria. In the rural community of Kano State, Nigeria, information on haematological changes in human malaria was scanty in spite of their role in the pathophysiology of malaria. This cross-sectional study was undertaken to determine blood cell profiles in malaria patients attending a rural hospital in malaria-endemic region.Methods:Blood samples (3ml each) were collected in EDTA-containers from 150 randomly selected outpatients attending Gaya General Hospital, screened for malaria using RDT kit (CareStart Malaria HRP 2, Access Bio Inc., USA) based on Histidine-rich protein 2 (PfHRP-2), and blood cell profiles determined using automated Sysmex haematologic analyser. Data on socio-demographics and medical history related to the study objectives, such as taking antimalarial regimen and/or haematinic, and direct involvement in blood transfusion, were obtained by questionnaire administration supplemented with oral interview Findings:The study revealed amalaria prevalence of 67.33%, with highest in 11-20years (80.95%) and lowest (55.00%) in 1-10years age-groups; slightly higher in females (68.25%) than in males (66.67%) without significant difference (P<0.05). For blood parameters, malaria positive patients have a significantly lower mean PCV of 32.2% as compared to 38.18% obtained for malaria negative patients (P<0.05). The mean Hb was 10.76±2.27g/dL and 12.65±2.38g/dL (P<0.05), while WBC revealed 6.91×109/L and 6.56×109/L in malaria positive and negative patients, respectively. Platelet counts recorded 179.24×109/L and 230.47×109/L (P<0.05). Socio-demographic factors such as level of education, occupation and marital status did not significantly influence malaria prevalence. Interpretation:Low PCV and Hb in malaria patients indicate mild anaemia due to malaria-related haemolysis. The occurrence of thrombocytopenia may be due to other underlying pathology as further studies with larger sample size are needed to ascertain the cause of low platelet counts in malaria patients in the study area
ABSTRACT
Healthcare network is composed of primary, secondary and tertiary care centers. Purpose of each unit in this sophisticated zone is to allow steady and smooth delivery of healthcare to optimum level without wasting essential resources or time. If, primary care centers are not able to fulfill the needs of any health issues then, patients are referred to more advanced setup where their health issues can be timely addressed in a proficient way. Referral system forms an important component of healthcare network and it should be formulated in such a way that it can bring fruitful results with the proper use of time, energy, man force as well as technical resources without compromising patient’s health. In this paper, we discussed the core of healthcare network in the city, working with primary as well as referral health care centers, flaws affecting the referral system and recommendations to improve them.
ABSTRACT
Objectives of the Study:An Epidemiological Research, a cross-sectional study, was conducted to determine the magnitude of human contamination of irrigation canal perimeter as it relates to the prevalence and intensity of schistosome cercarial infection in snail vectors.Place and Duration of Study:The study was conducted along water canal located within an irrigation area, Kano River Project Phase I, Kadawa, between January and June, 2012.Methodology:The study area was categorized into Zone of Heavy Contamination (ZHC), Zoneof Light Contamination (ZLC) and Zone of Free Contamination (ZFC) based on the density of faecal lumps observed along the canal perimeter using 1m2quadrat sampling technique. Snail vectors of schistosomiasis were collected from these zones, identified and subjected to cercarial shedding. Brevifurcate apharyngeate cercariae were identified as schistosome cercariae.Results:Of the 827 snails collected 28.54% shed schistosome cercariae. The breakdown of infection prevalence was 31.37%, 27.69% and 26.26% for ZHC, ZLC and ZFC respectively. Three snail species recovered in the study area, Bulinus globosus, B. rohlfsi and Biomphalaria pfeifferi had infection intensity of 8.6, 5.67 and 3.94 respectively, with total mean intensity of 4.67. A Chi-squared analysis did not show any significant difference in infection prevalence in the three zones (χ2cal.0.025, χ22, 0.05= 5.99). However, infection intensity was significantly different in the three zones and among the three snail species using analysis of variance (P<0.05). Conclusion:Human environmental contamination with faeces and urine around irrigation canals remains the source of infection to snail hosts and then to humans. It is presumed that contact control through avoidance of defaecation in the open and building of pit latrines near water contact points along irrigation canals will be effective means of drawing a barrier to infection with schistosomes in the study area