ABSTRACT
Retinopathy is the most common long-term complication of diabetes mellitus, and diabetic retinopathy is a complex disease, in which that inflammation plays a critical role. The aim of this study was to evaluate the association between insulin resistance as a known inflammatory marker and diabetic retinopathy in type 2 diabetes. In this study 342 patients with type 2 diabetes were enrolled, and their demographic data were recorded. HbA1c, FBS, lipid profiles and insulin levels were measured for all patients. Insulin resistance was calculated by the homeostatic model assessment of insulin resistance[HOMA-IR] formula. Following ophthalmologic examination [fundoscopy] patients were divided according to retinal involvement. The relation between HOMA-IR with diabetic retinopathy was evaluated. Mean age of patients was 55.05 +/- 9.8 years, and 30.4% of all patients had diabetic retinopathy. This analysis showed that HbA1c and duration of diabetes are the only independent predictive factors for diabetic retinopathy. Insulin resistance was not significantly different between patients with and without retinopathy but median level of HOMA-IR was significantly higher in patients with diabetic proliferative retinopathy compared with patients with non proliferative diabetic retinopathy [2.1[0.7- 6.6] Vs 1.2[0.5-2.8], P=0.021]. This data suggests that the insulin resistance may play a role in diabetic retinopathy in type 2 diabetes
ABSTRACT
The purpose of this study was to investigate the effects of acute treadmill exercise on Hsp72 and TAC in the hippocampus of diabetic rats. Forty male rats, weight 165 +/- 1 g, were assigned randomly into 4 groups: Diabetic control group, and 3 diabetic+acute training groups, including groups 1,2 and 3, the animals of which were sacrificed 30 minutes, 4 hours and 24 hours postexercise respectively. Diabetes was induced by injecting streptozotocin [STZ; 0/5 mg/kg dissolved in 0.1 M citrate buffer, pH 4.5] into the abdominal cavity. Rats were subjected to treadmill exercise, [treadmill speed 10 m/min, gradually increased to 18 m/min, grade 0%, duration exercise 60 min]. Data were analysed with one-way Anova and tukey post hoc, P
Subject(s)
Animals , Male , HSP72 Heat-Shock Proteins , Antioxidants , Diabetes Mellitus, Experimental , Hippocampus/metabolism , RatsABSTRACT
To evaluate the visual outcomes and complications of low power transpupillary thermotherapy [TTT] in patients with neovascular age-related macular degeneration [AMD]. The study included 20 eyes of 17 patients. Diagnosis of exudative AMD was established on the basis of fundus examination and fluorescein angiography [FA]. TTT was performed using a diode laser at 810 nm wavelength, spot size of 2.5 to 4 mm and duration of 60 seconds for each spot with power settings between 300-600 mw [20% reduction]. Follow-up visits were scheduled 1 and 6 weeks and 1, 3 and 6 months after the procedure and yearly thereafter. Patients were followed for at least 6 months. Cases with persistent leakage from CNV in late frames of FA were referred for another treatment option. Patients included 10 men [12 eyes] and 7 women [8 eyes] with mean age of 70.71 +/- 9.8 [range 50-84] years. Baseline best-corrected visual acuity [BCVA] ranged from 20/50 to 20/1300. Post-TTT regression of leakage [clinically and angiographically], and improvement or stabilization of visual acuity, was not statistically significant [P=0.14]. Post-TTT complications included subretinal prepapillary hemorrhages in 2 eyes, vitreous hemorrhage in 2 eyes and macular infarction in one eye. At final follow-up, fibrosis of the CNV was detected in 7 [35%] eyes and flat chorioretinal atrophy with hypopigmentation was seen in 11 [55%] eyes. There was no significant difference between cases with flat atrophy and those with fibrous scars in terms of BCVA [P=0.91]. Subgroup analysis showed that patients with better visual acuity [>/=20/60] had poorer visual outcomes after TTT [P=0.03]. Overall, in spite of the low threshold, visual acuity remained unchanged or decreased. Although TTT can occlude choroidal neovascularization, it could not prevent retinal complications and occurrence or progression of chorioretinal atrophy or subretinal fibrosis
ABSTRACT
Since anticoagulant therapy during pregnancy has high fetal and maternal risks, using bioprostheses valve is recommended for young women with cardiac valve disease who hope to have Children. Evaluation of the effect of pregnancy on the rate of deterioration of bioprosthetic valve is the aim of this study. This case - control study was done on 53 women in the reproductive age who underwent cardiac valve replacement using bioprostheses during 1977- 2001. Twenty seven patients [mean age 22. +/- 7.73 yr] at the time of valve replacement had pregnancy [Group A], and 26 patients [mean age 26.8 +/- 10.9] had no pregnancy after valve replacement [group B]. Mean time of structural valve deterioration, and need for redo valve surgery compared between the two groups. In group A 81.48% of patients underwent mitral valve replacement [MVR], 14.81 aortic valve replacement [AVR], and 3.71% tricuspid valve replacement [TVR]. In group B 84.6% underwent MVR, 11.6% AV R, and 3.81% both MVR and AVR. Fifty six pregnancy occurred in group A which 19.6% of them ended with abortion, 76.8% had normal infant birth 94.64% of pregnancies had no complications and 5.3% had valve degeneration during or 2-4 months after delivery. Average time of freedom from structural valve deterioration in the patients who had pregnancy was 16.60 years and it was 16.74 years in patients who had no pregnancy [P=0.91]. 55.5% of patients in group A underwent redo valve replacement [14.46. +/- 5.4yr] after first operation and 50% in group B after [10.61 +/- 5.63 yr] underwent redo valve replacement. Our finding didn't show any differences in structural valve deterioration time or need for redo valve operation between pregnant and non pregnant patients