ABSTRACT
Abstract Introduction: According to the World Health Organization [WHO] classification Lymphoid neoplasms are categorized into 3 major groups: Hodgkin's disease [HD] and the non-Hodgkin's lymphomas [NHL] of B-cell or T-cell/natural killer [NK] cell origin. Few dedicated reports have been published about metabolic imaging by FDG-PET CT in different subtypes of NHL accordig to who classification
Objective: Determine the reliability of FDG-PET-C Tin detection of different subtypes of NHL according to using the WHO classification
Materials and Methods: In a total of 164 patients with a histological proven non-Hodgkin lymphoma, FDG-PET/CT imaging was performed for staging [n=138] and restaging [n=26]. FDG-uptake pattern according to different lymphoma subtypes was qualitatively evaluated
Results: Distinctive FDG-uptake could reliably be seen in one site of all patients with DLBCL [n=77], mediastinal large b-cell lymphoma [n=12], mantel cell lymphoma [n=5], PTLD [n=5], anaplastic large cell [t cell] lymphoma [n=6], precursor B lymphoblastic lymphoma [n=1], plasmacytoma of sternum [n=2], splenic marginal zone lymphoma [n=1], precursor t lymphoblastic lymphoma of thymus [n=1], extranodal NK/t cell NHL NASAL type [n=3], primary cutaneous anaplastic large cell [t cell] lymphoma [n=2], angioimmuoblastic t cell lymphoma [n=1] and Burkitt lymphoma [n=2]. One case of small lymphocytic lymphoma and one case of CLL were not detected by PET/CT. Evaluation of follicular lymphoma [86% positive] and MALT lymphoma [83% positive] revealed less reliable results
Conclusion: T-cell lymphomas and most B-cell lymphomas can be reliably evaluated by FDG-PET/CT imaging