[Relation between serum ghrelin concentration and blood glucose levels in type-2 diabetic obese males]

Ghrelin is an acylated 28-amino-acid peptide that is the most recently identified adipocytokines, but its role in diabetes is poorly clarified. The objective of this study was to determine the relation between serum ghrelin and blood glucose levels in type 2 diabetic obese males. This descriptive study was done on 45 adult obese males with type-2 diabetes in Saveh city, Iran during 2010. Fasting blood glucose, insulin and ghrelin concentrations and Glycosylated hemoglobin HbA1C were measured after overnight fasting. Multiple regression was used for determine ghrelin in relation to glucose, insulin and HbA1C. The multiple regression analyses revealed that HbA1C is not correlated with serum ghrelin levels, while, fasting blood glucose level had positive corrolation with serum ghrelin concentration [P<0.05]. Serum ghrelin level had high negative correlation with insulin [P<0.05]. This study indicated that elevated endogenous ghrelin led to hyperglycemia. Therefore, serum ghrelin is a precise index of blood glucose level in obese male patients with type-2 diabetes

[Investigation of the relationship between adiponectin and beta-cell function in patients with type II diabetes]

Although both insulin resistance and beta cell dysfunction contribute to pathogenesis of type II diabetes, the role of adiponectin in beta cell function has received limited attention. The objective of this study was to determine the relationship between serum adiponectin level and beta cell function. Forty one non athletes fat adult men between 35 and 50 years of age [BMI >/= 30] with type II diabetes were enrolled in this study. Serum concentrations of adiponectin, glues, triglyceride and insulin were measured after 10-12 hours overnight fasting in all participants. Beta cell function was assessed by measuring fasting glucose and insulin level. After data collection, we used Pearson correlation test to determine the relationship between adiponectin and beta-cell function in patients with type II diabetes [p

[ effect of chronic intake of L-carnitine L-tartrate on lipid metabolism during aerobic exercise]

Despite 20 years of research, there is no compelling evidence about the effect of carnitine supplementation on improving physical performance in healthy subjects. The aim of this study was to determine the effect of long term consumption of acute L-carnitine L-tartarate [LCLT] on fat metabolism and aerobic capacity. A total of 28 healthy nonathlete male students received either L-carnitine L-tartarate or placebo [Lactose] for 3 weeks [3g orally, daily] in experimental and control groups. The subjects of both groups performed submaximal ergometery Astrand protocol on bicycle for 20 minutes before and after this supplementation period. Following each test, blood samples were drawn immediately to determine the concentrations of plasma free fatty acid [FFA], triglyceride [TG] and other metabolites. Resting and submaximal heart rates were monitored. The collected data of pre and post tests were evaluated by SPSS 13.0 software in the both groups. No significant differences in FFA, TG and resting and exercise heart rates were found between pre and post tests in the both experimental and control groups.Three weeks LCLT supplementation has no effect on fat metabolism and aerobic capacity. Also, chronic intake of LCLT has no effect on substrate utilization or endurance performance in healthy individuals