ABSTRACT
The toxic effect of daily oral stomach intubation of Oxamyl at dose levels of 0.9, 2.2 and 3.5 mg/kg rat body wt, for 16 days was investigated. The changes in rat blood parameters were measured after 3, 5, 9, 13 and 16 days of the treatment. Oxamyl inhibited acetylcholinesterase considerably. At the level of 3.5 mg/kg, the insecticide led to an increase of total plasma protein, 5 days post treatment. The changes of the electrophoretic pattern of plasma protein fractions from normal, showed an increase in Albumin, Alpha-1 globulin and Beta-globulin and a decrease in Alpha-2 globulin and Gamma globulin. Oxamyl altered hemoglobin concentration, and caused changes in acid and base buffer capacities of Hb,. The most significant decrease in acid buffer capacity accompanied by an increase in base buffer capacity was observed after 9 and 5 days after treatment with 0.9 and 2.2 mg/kg respectively. This finding is attributed to the unfolding of Hb. and the accompained changes in hydrophilic / hydrophobic ratio. An evidence of a conversion of oxyhemoglobin [HbO2.] to methemoglobin [MetHb] as well as a formation of sulfhemoglobin [SHb.] was also observed