ABSTRACT
Tuberculosis [TB] is an important issue which its control is still unsatisfactory at global level. Traditional diagnostic techniques for active TB diagnosis are inadequate: the diagnostic gold standard is the culturel exam which suffers from lengthy processing and requires highly specialized laboratories. Nowadays more specifie tests hâve been recommended. The aim of this study is to evaluate the performance of Quanti FERON-TB [QFT] Gold In Tube-Test as a substitute for specifie test tuberculin skin test for diagnosis of latent tuberculosis infection in high risk groups. One hundred thirty four [134] individuels who worked in Bo-Ali hospital [Zahedan] enrolled in this study. They had no active tuberculosis. TST and QFT tests were performed. The cut-off point of TST was considered based on 15 [mm] or more indurations as positive. The resuit of QFT was evaluated by manufactured guidelines. Multivariate logistic regression was used to identify the putative risk factors of positive tests. Proportion of employees with latent TB were 1 1 1 [82.8%] were positive by either TST or QFT, and 76[56.7%] were positive by both tests. Agreement between the tests was high [73.8%, k=0.39; 95% E.21-0.44]. Positive family history of Tuberculosis was significant risk factor for both positive tests. This study showed high latent tuberculosis infection prevalence in hospital workers and high agreement between TST and QFT. Decision to select one of the tests will be depended on the population, purpose of study and availability of resources. The results revealed that the QFT can be appropriate alternative test for high risk group
ABSTRACT
Background: because of increase in number of side effect that caused by hypovitaminosis D, this study has been done to find out prevalence of hypovitaminosis D in blood donors
Methods and Materials: in this Cross - sectional and descriptive study, we evaluated 183 persons, 163 male [89.07%] and 20 female [10.92%]. The average range of women and men was 17-52y and 17-53y respectively
Results: the results revealed that 8 persons [4.4%] had sever hypo vitaminosis D [vit<25 nmol/l]. 124 persons [67.8%]: mild hypovitaminosis D [vit D=25-62.4nmol/l], 45 persons [24.6%]: normal serum level of vit D [62.5-125 nmol/l] and 6 persons [3.3%] had hyper vitaminosis D [> 125 nmol/l]. Prevalence of hypocalcemia and hypophosphatemia in blood donors was 95 persons [51.9%] and 10 persons [5.5%] respectively. Also average serum level of PTH was 32.1 +/-33. 4 pg / ml
Conclusions: the above finding suggests a solid and effective programming for education of people about prevalence and complications of hypovitaminosis D, more effective screaming studies for improving knowledge of individual about prevalence of hypovitaminosis D and related disease in society and necessity of medical health personnel's knowledge about hypovitaminosis D