ABSTRACT
Introdution: The Philadelphia chromosome was the first cytogenetic abnormality specific of malignant process. In 1960 Nowell and Hungerford associated this abnormality to the chronic myeloid leukemia. It's reciprocal translocation between the chromosome 9 [breakpoint: q34] and the 22 [breakpoint: q11]
Material and methods: We have searched the Ph1 chromosome with cytogenetic analysis at 170 patients affected by Chronic Myeloproliferative Disorders . Eighty nine patients were at the diagnosis step, six in acutisation, and seven in relapse, twelve in clinical remission. The evolutionary stage is unknown in the other cases
Results: The Ph1 chromosome: t [9;22][q34;q11] was found in 116 cases
Discussion: We discuss in this study, the interest of the Ph1 chromosome in order to confirm the diagnosis of chronic myeloid leukemia and to follow the patients under Interferon and imatinib [Glivec[*]]