ABSTRACT
Portulaca oleracea [P.O] overgrows in the different parts of Iran, that is used there as both a salad green and a medicinal plant. In previous studies, a 10% ethanolic extracts of the aerial parts [Leaf and stem] of PO showed anti-nociceptive activity in mice and rats. This study was designed to evaluate anti-nociceptive effects of different doses of the aqueous decoction extracts of PO [Seed]. In this study, 65 male mice [25-30 gr] in model tail flick were used. Different doses of the extract 25, 50, 75, 100 mg/kg [IP] were injected to the separated groups of four [Test group] and water [10 ml/kg-IP] was injected to the one control group. The anti-nociceptive effect was determined 15 and 30 min after injection [N=15 mice for pilot study]. The results showed that there was a significant difference between two groups [P<0.05], but the animals of test groups did not show significant difference in different doses and time. It is concluded that the aqueous extract of PO has anti-nociceptive activity, which is not related to dose and time