HLA and atopic dermatitis

The present study included 20 patients with atopic dermatitis [AD]. These patients comprised 2 groups; the first group included 10 patients with only AD [pure AD], the second group included 10 patients with AD and respiratory manifestations of bronchial asthma [AD with BA]. These patients as well as 10 normal individuals as a control group were subjected to HLA typing using lymphocyte microcytotoxicity testing. Serum total IgE was determined in the patients and control group. The results of the present study showed no significant difference between patients and control. The results of HLA typing of patients subgroups [only AD, AD with BA] were compared to control. It was found that HLA-A1 was significantly higher in patient groups in comparison to control group as P <0.05 and P <0.01, respectively. HLA-B8 was not significantly higher in patient groups in comparison to control as RR was 0.58 and 1, respectively. HLA-A3 was significantly increased in patient groups in comparison to control as P <0.05 and P <0.05, respectively. HLA-B7 was significantly increased in patient groups in comparison to control as P <0.01 and P <0.01, respectively. The present study also revealed the serum total IgE to be significantly increased in both groups of patients in comparison to control group. It was evidented that the amount of serum total IgE in cases of AD is much less than that in cases suffering from AD with BA. These results were discussed

Hypertension as cardiovascular risk factor in diabetic patients

To determine the effect of elevated arterial blood pressure on diabetic as cardiovascular risk factor, 40 subjects of different ages and sexes were study. The best predictor of all causes of mortality and cardiovascular death in the studied groups of diabetic patients are B2 macroglobin, cholesterol, triglycerides, HDL, and LDL. The results indicated that, rise in systolic BP is a powerful contributory factor to cardiovascular complication. On the other hand, the diastolic BP is a risk cardiovascular factor, especially in old ages. The study also confirmed the role of SBP, HbAl, B2MG, HDL and LDL as a risk factors. There is no significant role of the duration of the disease, cholesterol level, triglycerides, and DBP as a risk factors. Treatment of hypertension is benefit to the diabetic patients to lower the accelerated atherogenesis as in non diabetic patients