Effect of mercury on the immune response and mean intensity of Hymenolepis Nana infection in mice

The effect of mercury on selected immunological parameters was studied in mice with experimental H. nana infection. T-lymphocytes and serum protein changes in mice treated for varying duration with mercuric chloride [HgCl2] and subsequently infected with 1000 H. nana eggs were compared with their counterpart controls: an only treated and an only infected groups. Decreased values of T-lymphocytes beta and gamma globulins in the mercury-treated control group indicate suppression of immune response by mercury. The subsequent infection of HgCl2-intoxicated animals elevated the studied immunological parameters along with higher worm recoveries in comparison with infected non-intoxicated mice, but these immunological parameters remained significantly suppressed

Topical metronidazole for severe and resistant cases of rosacea

Topical metronidazole 0.75% aqueous gel twice daily for 8 weeks was tried in 22 patients with either severe or resistant acne rosacea. Assessment of each case using investigator global assessment, scores for edema and erythema and number of inflammatory lesions was done before treatment and after 4 and 8 weeks of therapy. While, 18 out of 22 patients [81.8%] showed marked improvement, 2 patients [9.1%] were unchanged, and another 2 cases [9.1%] have got worse at the end of the 8 weeks. The drug was found to be tolerable and safe to all patients