In situ characterization of B-and T-lymphocytes in basal cell carcinoma of the head and neck region

Twenty cases of basal cell carcinoma [BCC] of the head and neck region were examined immunohistochemically for the detection of T- and Blymphocytes. The results showed that the dense lymphocytic infiltrate surrounding neoplastic cells of BCC consisted chiefly of T-lymphocytes. The lymphocytic infiltrate revealed in parts a pattern of a small lymphocytic follicle with peripherally situated T cells and central B cells. The predominance of Tlymphocytes in BCC suggests a local cell-mediated immune response. However, the presence of B-lymphocytes indicates a possible humoral immune reaction. T cells may be responsible for regulating the proliferation, and thus the growth, of malignant epithelial cells in BCC

Malignant peripheral neuroectodermal tumors [MPNT]: a study of 40 cases including MPNT of jaw in infancy

Malignant peripheral neuroectodermal tumors [MPNT] form a distinct entity from other malignant small round cell tumors, by their light and electron microscopic features. Forty patients with these tumors including malignant melanoma, primary and metastatic, shwannoma, neurofibroma, Ewing's sarcoma, retinoblastoma, granular cell myoblastoma and MPNT of the jaw of infants were included in this study. The neuroectodermal origin of these tumors was proven in 36 of 40 patients [90%] as demonstrated by their positive reaction to neuron specific enolase [NSE] and S-100 protein on immunohistochemical evaluation