ABSTRACT
This study was performed on 120 pregnant women at early pregnancy. They were divided into two groups: The control group [I] included 30 normal pregnant women with no history of abortion and the study group [II] included 90 pregnant women with history of two or more unexplained abortion who were further subdivided randomly into three subgroups. All patients in the subgroups were given folic acid and low-dose aspirin; they were given alone to patients in group IIa, patients in group IIb received also nitroglycerine 5 TTS skin patches [5 mg each] and patients in group IIc were given 1.2 MIU of long- acting penicillin every two weeks. Doppler study of the uterine artery blood flow was performed at the time of vaginal ultrasound examination at different intervals of gestational age for all patients in all groups. A follow up of pregnancy was done every 2 weeks till 20 weeks [age of viability] or abortion occurred. The study concluded that uterine artery Doppler indices [resistivity index, RI, and pulsatility index, PI] significantly decreased with the increasing gestational age. Treatment with folic acid, pediatric aspirin, nitroglycerine patches and long-acting penicillin resulted in Doppler indices close to the control group results and in a better pregnancy outcome